Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials

Ahmadi, Amirhossein; Hosseini-Nami, Samira; Abed, Ziaeddin; Beik, Jaber; Aranda-Lara, Liliana; Samadian, Hadi; Morales-Ávila, Enrique; Jaymand, Mehid; Shakeri‐Zadeh, Ali

doi:10.1016/j.drudis.2020.09.026

Cited by 41 publications

(44 citation statements)

References 179 publications

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“…Recently, the field of nanotechnology has emerged significant progress with the ability to produce nanoparticles from different sources with substantial promises in diverse biomedical applications including drug delivery [ 417 ]. The combination of nanomaterials with stimuli-responsive hydrogels has endowed targeted drug delivery, minimized possible risk factors, and improved therapeutic outcomes [ 418 , 419 ]. Smart/stimuli-responsive hydrogels have confirmed remarkable findings regarding drug delivery applications.…”

Section: Smart/stimuli-responsive Hydrogels Employed For Different Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

222

139

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Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engineering and other biomedical purposes. They can simulate the physicochemical, mechanical, and biological characters of the innate tissues. Also, they provide the aqueous conditions for cell growth, support 3D conformation, provide mechanical stability for the cells, and serve as potent delivery matrices for bioactive molecules. Many natural and artificial polymers were broadly utilized to design these intelligent platforms with novel advanced characteristics and tailored functionalities that fit such applications. In the present review, we highlighted the different types of smart/stimuli-responsive hydrogels with emphasis on their synthesis scheme. Besides, the mechanisms of their responsiveness to different stimuli were elaborated. Their potential for tissue engineering applications was discussed. Furthermore, their exploitation in other biomedical applications as targeted drug delivery, smart biosensors, actuators, 3D and 4D printing, and 3D cell culture were outlined. In addition, we threw light on smart self-healing hydrogels and their applications in biomedicine. Eventually, we presented their future perceptions in biomedical and tissue regeneration applications. Conclusively, current progress in the design of smart/stimuli-responsive hydrogels enhances their prospective to function as intelligent, and sophisticated systems in different biomedical applications.

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Section: Smart/stimuli-responsive Hydrogels Employed For Different Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

222

139

View full text Add to dashboard Cite

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“…To circumvent the limitations caused by the hydrophobicity of sonosensitizers, lipid-sonosensitizers were encapsulated in bilayered delivery systemsliposomes and micelles. − Liposomes are phospholipid-based bilayered vesicles that can easily carry both hydrophilic and hydrophobic sonosensitizers . Wen et al encapsulated a hydrophobic drug in a sonosensitive liposome that can be activated by exposing ultrasound.…”

Section: Sonosensitizers and Delivery Systemsmentioning

confidence: 99%

Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives

Roy

Pandey

Gupta

et al. 2021

ACS Biomater. Sci. Eng.

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Multidrug-resistant bacteria have emerged in both community and hospital settings, partly due to the misuse of antibiotics. The inventory of viable antibiotics is rapidly declining, and efforts toward discovering newer antibiotics are not yielding the desired outcomes. Therefore, alternate antibacterial therapies based on physical mechanisms such as light and ultrasound are being explored. Sonodynamic therapy (SDT) is an emerging therapeutic approach that involves exposing target tissues to a nontoxic sensitizing chemical and low-intensity ultrasound. SDT can enable site-specific cytotoxicity by producing reactive oxygen species (ROS) in response to ultrasound, which can be harnessed for treating bacterial infections. This approach can potentially be used for both superficial and deep-seated microbial infections. The majority of the sonosensitizers reported are nonpolar, exhibiting limited bioavailability and a high clearance rate in the body. Therefore, targeted delivery agents such as nanoparticle composites, liposomes, and microbubbles are being investigated. This article reviews recent developments in antibacterial sonodynamic therapy, emphasizing biophysical and chemical mechanisms, novel delivery agents, ultrasound exposure and image guidance strategies, and the challenges in the pathway to clinical translation.

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“…Additional methods to trigger the release of biomolecules from biomedical devices and scaffolds aided by external activation involve the use application of electrical and/or magnetic fields as well as by acoustic and/or ultrasound stimulation ( Moncion et al, 2017 ; Gao et al, 2019 ; Ahmadi et al, 2020 ; Lu et al, 2020 ; Oliva and Almquist, 2020 ; Thébault et al, 2020 ). Ultrasound-sensitive microbubbles, liposomes, and emulsions have advanced the field of ultrasound-triggered drug delivery systems as they undergo the phenomenon of cavitation and destruction followed by encapsulated drug release.…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

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In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

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Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials

Cited by 41 publications

References 179 publications

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

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