Recent advances in understanding Crimean–Congo hemorrhagic fever virus

Hawman, David W.; Feldmann, Heinz

doi:10.12688/f1000research.16189.1

Cited by 91 publications

(70 citation statements)

References 88 publications

(117 reference statements)

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“…Examples of tick-borne viruses of importance for animal and/or human health are African swine fever virus transmitted by Ornithodoros spp. [9], Crimean-Congo hemorrhagic fever virus (CCHFV) transmitted by Hyalomma ticks [10] and tick-borne encephalitis virus transmitted by Ixodides ticks [11]. As mentioned earlier, the ecology of these viruses, normally includes the circulation of the virus between a reservoir animal and the tick species.…”

Section: Introductionmentioning

confidence: 99%

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Novel Viruses Found in Antricola Ticks Collected in Bat Caves in the Western Amazonia of Brazil

Blomström

Luz

Öhlund

et al. 2019

Viruses

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In this study, we describe the viral composition of adult Antricola delacruzi ticks collected in a hot bat cave in the state of Rondônia, Western Amazonia, Brazil. A. delacruzi ticks, are special, compared to many other ticks, in that they feed on both bats (larval blood feeding) and bat guano (nymphal and adult feeding) instead of feeding exclusively on vertebrate hosts (blood feeding). Considering this unique life-cycle it is potentially possible that these ticks can pick up/be infected by viruses not only present in the blood of viremic bats but also by virus shed through the bat guano. The viral metagenomic investigation of adult ticks showed that single-stranded negative-sense RNA viruses were the dominant group of viruses identified in the investigated ticks. Out of these, members of the Nairoviridae family were in clear majority constituting 88% of all viral reads in the data set. Genetic and phylogenetic analyses indicate the presence of several different orthonairoviruses in the investigated ticks with only distant relationship to previously described ones. In addition, identification of viral sequences belonging to Orthomyxoviridae, Iflaviridae, Dicistroviridae, Polycipiviridae, Reoviridae and different unclassified RNA viruses showed the presence of viruses with low sequence similarity to previously described viruses.

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Section: Introductionmentioning

confidence: 99%

“…For example, in the case of CCHFV the main viral reservoir is the tick itself with several amplifying hosts, such as hares, deer and domestic livestock. Humans can be infected via tick bites or when handling infected animals [10].…”

Section: Introductionmentioning

confidence: 99%

Novel Viruses Found in Antricola Ticks Collected in Bat Caves in the Western Amazonia of Brazil

Blomström

Luz

Öhlund

et al. 2019

Viruses

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“…Some cases of gastric adenocarcinoma are associated with EBV. Merkel cell polyomavirus is responsible for causing a vast majority of Merkel cell carcinoma tumors (Haley et al, 2018;Arora et al, 2012;Bosch and De Sanjosé, 2003;Bower et al, 2003;Centers for Disease Control and Prevention (CDC) 2012;Chaturvedi et al, 2009;Fukayama et al, 1994).…”

Section: Tumors and Viruses Renewable Relationsmentioning

confidence: 99%

General Introduction to Volume 1 Emergent and Reemergent Viruses: Modern Important Issues

Ennaji

2020

Emerging and Reemerging Viral Pathogens

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“…Tıbbi bakım ve dolaşan viral suşlardaki farklılığın mortalitede farklılığa neden olduğu düşünülmekte fakat bununla ilgili dökümente edilmiş bilgiye ulaşılamamaktadır (1,8).…”

Section: Introductionunclassified

Molecular Analysis of Crimean-Congo Hemorrhagic Fever Virus Among Fatal and Non-fatal Cases in Tokat Province

Çağlayık¹,

Bayrakdar²

2020

atfm

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Objectives: Crimean-Congo hemorrhagic fever (CCHF) is seen in our country with fatality rate of 5% since 2002. It was aimed to reveal if there were any differences responsible from fatalities in M segments of CCHF viruses detected in patients' sera in Tokat province, reporting the most of the cases in Turkey. Materials and Methods: Nineteen patients, applying to hospital whom, nine were later ex and 10 were discharged with cure, from the same regions of Tokat districts between March to August 2014, which is the period of most number of CCHFV cases reported, were included. Viral RNA was isolated, M segment region was amplified and sequence analysis was performed. Results: Obtained M segment nucleotide sequences were found to be in Europe clade having close relation with Russian and Kosovo strains on the same branches of the phylogenetic tree. Seven out of 19 viruses were in a different group because they had R1532K mutation like Russian and Kosovo strains and L1601F mutation which was not found to exist in the genotypes reported from Turkey, before. Conclusion: In this study, Turkey/Almus01/2014 M segment analysis was found identical in a couple living in Almus, whom one of them had died while one was discharged from hospital with cure, suggesting individual factors were also responsible from fatality, not only viral strain. On certain periods although suspicion of high mortality rate occurs, at the end of each disease season, fatality stays on the same rate, suggesting there are not any viral mutations increasing fatality. Data on this study support this hypothesis.

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Recent advances in understanding Crimean–Congo hemorrhagic fever virus

Cited by 91 publications

References 88 publications

Novel Viruses Found in Antricola Ticks Collected in Bat Caves in the Western Amazonia of Brazil

Novel Viruses Found in Antricola Ticks Collected in Bat Caves in the Western Amazonia of Brazil

General Introduction to Volume 1 Emergent and Reemergent Viruses: Modern Important Issues

Molecular Analysis of Crimean-Congo Hemorrhagic Fever Virus Among Fatal and Non-fatal Cases in Tokat Province

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