Recent advances in understanding dengue

Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

doi:10.12688/f1000research.6233.1

Cited by 46 publications

(45 citation statements)

References 101 publications

(106 reference statements)

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“…60 Mainly present in South and Southeast Asia, it has recently exploded in other parts of Asia, Latin America, and the Caribbean. Dengue presents as a variety of clinical phenotypes ranging from mild to severe disease with capillary leak, coagulopathy, and organ impairment, which may be in part immune mediated.…”

Section: Related Viruses: Similarities and Differencesmentioning

confidence: 99%

Zika virus: An emergent neuropathological agent

White

Wollebo

Beckham

et al. 2016

Annals of Neurology

113

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The emergence of Zika virus in the Americas has followed a pattern that is familiar from earlier epidemics of other viruses, where a new disease is introduced into a human population and then spreads rapidly with important public health consequences. In the case of Zika virus, an accumulating body of recent evidence implicates the virus in the etiology of serious pathologies of the human nervous system, that is, the occurrence of microcephaly in neonates and Guillain–Barré syndrome in adults. Zika virus is an arbovirus (arthropod-borne virus) and a member of the family Flaviviridae, genus Flavivirus. Zika virions are enveloped and icosahedral, and contain a nonsegmented, single-stranded, positive-sense RNA genome, which encodes 3 structural and 7 nonstructural proteins that are expressed as a single polyprotein that undergoes cleavage. Zika genomic RNA replicates in the cytoplasm of infected host cells. Zika virus was first detected in 1947 in the blood of a febrile monkey in Uganda’s Zika Forest and in crushed suspensions of the Aedes mosquito, which is one of the vectors for Zika virus. The virus remained obscure, with a few human cases confined to Africa and Asia. There are two lineages of the Zika virus, African and Asian, with the Asian strain causing outbreaks in Micronesia in 2007 and French Polynesia in 2013–2014. From here, the virus spread to Brazil with the first report of autochthonous Zika transmission in the Americas in March 2015. The rapid advance of the virus in the Americas and its likely association with microcephaly and Guillain–Barré syndrome make Zika an urgent public health concern.

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Section: Related Viruses: Similarities and Differencesmentioning

confidence: 99%

Zika virus: An emergent neuropathological agent

White

Wollebo

Beckham

et al. 2016

Annals of Neurology

113

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“…The clinical spectrum of dengue disease is broad ranging from fever to severe disease with evidence of plasma leak, which can lead to death [8]. Dengue can be caused by any of four related viruses, termed serotypes (DENV1-4).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in human flavivirus vaccines

Scherwitzl

Mongkolsapaja

Screaton

2017

Current Opinion in Virology

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“…Latest estimates suggest 390 million infections of dengue occur each year, of which 100 million results in symptomatic disease [1].…”

Section: Introductionmentioning

confidence: 99%

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

Ruiz¹,

Vázquez²,

Villegas³

et al. 2017

OALib

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Latest estimates suggest 390 million infections of dengue occur each year, of which 100 million results in symptomatic disease. The new clinical classification proposed by WHO-TRD 2009 simplifies dengue fever (DF) into dengue (D) and severe dengue (SD) with an intermediary group of "dengue with warning signs" (DWS). Early, sensitive and specific diagnosis of dengue is needed for appropriate patient management as well as for early epidemic detection. Virological and serological markers in sera from dengue confirmed patients from Venezuela and Nicaragua were evaluated. A total of 232 sera collected in the acute (days 1 to 5 of fever onset) and convalescent (days 7 to 14) phases of illness were tested by Platelia NS1 antigen ELISA and IgM, IgA and IgE capture ELISA methods. NS1 was detected with highest OD values in the acute phase for primary and secondary cases. IgM was detected in primary and secondary groups but the highest OD figures were observed after defervescence day. IgA and IgE detection were almost absent for primary cases, contrary to secondary cases which showed higher values but after defervescence day. NS1 could be used as effective diagnostic marker in the acute phase of illness for primary and secondary dengue infections. IgM detection is still an invaluable tool for routine dengue diagnosis but delay. IgA detection could define secondary infection in early phase of illness. IgA/IgE could be evaluated as prognostic markers associated to SD cases.

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Recent advances in understanding dengue

Cited by 46 publications

References 101 publications

Zika virus: An emergent neuropathological agent

Zika virus: An emergent neuropathological agent

Recent advances in human flavivirus vaccines

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

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