Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Abstract

Researchers have developed dozens of cancer treatment strategies to address the high proportion of cancer deaths in total deaths. However, the treatment of cancer inevitably has various drawbacks and sequelae....

Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

“…A recent study by Li, M. et al demonstrates the potential use of MOFs as an antitumor drug delivery system through various methods of tumor exposure and depletion. The methods can be categorized into chemotherapy, photodynamic therapy, photothermal therapy, chemical kinetic therapy, sonodynamic therapy, immunotherapy, gene therapy, and starvation therapy [ 40 ]. Considering the novelty and relevance of this development, it cannot be said that such a solution is suitable as a delivery system for immunobiological substances for intranasal administration and not only.…”

Coordination Polymer Based on a Triangular Carboxylate Core {Fe(μ3-O)(μ-O2CR)6} and an Aliphatic Diamine

“…Coordination polymers are formed by binding metal ions or metal-containing cores with bridging ligands, whose variation in structure-forming parameters allows for control over the polymer's structure [1][2][3][4][5][6][7][8][9][10], as well as luminescent [11][12][13][14], sorption [4,[15][16][17][18], magnetic [19][20][21][22], and other properties. Iron(II) coordination polymers exhibit selective catalytic activity in the hydroboration of aldehydes and ketones [23], the oxidative functionalization of alkanes [24], and in dimerization reactions of aromatic halogen derivatives [25].…”

Biomimetic ZIF-8 Nanoparticles: A Novel Approach for Biomimetic Drug Delivery Systems

“…6 Among the MOFs, some Zn-MOFs can prevent the aggregation and self-destruction of photosensitisers (PSs) and reactive oxygen species (ROS), which allows them to effectively load PSs, and the chemical structure characteristics of Zn-MOFs allow them to be embedded into a wide range of biomolecules for therapeutic use through simple synthesis. 7 ZIFs, a type of MOF material, are coordination polymers formed by bridging transition metals, such as zinc, with imidazole (Imi) or imidazole derivatives through nitrogen atoms. 8 Zinc, the second most abundant transition metal in living organisms, is known to be beneficial for bone health and repair as it protects bone.…”

“…6 Meanwhile, Li et al explored the synthesis of Zn-MOF and its use in cancer chemotherapy, phototherapy, chemodynamic therapy, sonodynamic therapy, immunotherapy, gene therapy, starvation therapy, or a combination of two or more of the above therapies. 7 Unlike them, this review focuses on the application of biomimetic material-modified ZIF-8 as drug delivery systems in disease.…”