Recent advances of 5-endo-trig radical cyclization: promoting strategies and applications
Yulu Zhou,
Sangxuan Xu,
Xuemei Zhang
et al.
Abstract:The 5-endo-trig radical cyclization has long been recognized as one of the most straightforward ways for the construction of densely functionalized five-membered rings. Nevertheless, according to Baldwin's rules, the 5-endo-trig...
A photocatalytic sulfamoylation/5-endo-trig cyclization of (E)-N'-arylidene-N-phenylmethacrylohydrazides with sulfamoyl chlorides was developed. The chemoselective intramolecular addition of the carbon-centered radical intermediate to the C=N bond in hydrazone motif gave the sulfamoylated...
A photocatalytic sulfamoylation/5-endo-trig cyclization of (E)-N'-arylidene-N-phenylmethacrylohydrazides with sulfamoyl chlorides was developed. The chemoselective intramolecular addition of the carbon-centered radical intermediate to the C=N bond in hydrazone motif gave the sulfamoylated...
A novel three-component radical cyclization/haloazidation of enynones, employing TMSN3 as the azide source and NIS (NBS or NCS) as the halogen source, has been developed under metal-free conditions for the...
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