Recent Advances of Actinomycetes

Kim, Eung-Soo

doi:10.3390/biom11020134

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…A descoberta da produção de metabólitos secundários por parte dos endofíticos se estabeleceu principalmente com o filo Actinomicetos, um grupo de bactérias gram-positivas, como o gênero Streptomyces, que desempenham papel fundamental nos campos da medicina humana e seus setores de biotecnologia ao longo das últimas décadas (Barka et al, 2016;Kim, 2021).…”

Section: Metabólitos Secundáriosunclassified

Importância dos metabólitos secundários produzidos por actinobactérias

Costa Rosa,

Gonçalves Mota,

Lima de Almeida

et al. 2023

rcs

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Este artigo consiste em uma revisão de literatura sobre os aspectos mais relevantes das actinobactérias e seus bioprodutos. As actinobactérias são bactérias Gram-positivas com propriedades morfológicas de células fúngicas (micélio aéreo e vegetativo) e bacteriana. São amplamente distribuídas na natureza, sendo comumente isoladas de solo, água, sedimentos, plantas, plantas em decomposição, nódulos de raízes, lodo ativado, fezes de animais e produtos alimentícios; além de estarem distribuídas em habitats aquáticos e ambientes extremos como áreas congeladas, solos desérticos e zonas abissais, lugares considerados ideais para que os microrganismos produzam metabólitos secundários. Cerca de mais de 23.000 metabólitos microbianos são conhecidos, dos quais 32% são produzidos por actinomicetos. Os metabólitos secundários podem ser utilizados como modelo para síntese e semi-síntese de moléculas bioativas de amplo espectro e baixa toxicidade. Portanto, são diversas as aplicações esperadas para as actinobactérias, e cada vez mais a utilização de compostos bioativos, de origem natural, para o tratamento de diversas doenças, são incorporados na indústria farmacêutica. Entretanto, as actinobactérias ainda são pouco estudadas, principalmente as endofíticas, necessitando de mais pesquisas na área, pois a literatura ainda carece de estudos aprofundados dentro desse tema.

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Section: Metabólitos Secundáriosunclassified

Importância dos metabólitos secundários produzidos por actinobactérias

Costa Rosa,

Gonçalves Mota,

Lima de Almeida

et al. 2023

rcs

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“…Actinomycetes are a group of unicellular filamentous bacteria widely distributed in soil, freshwater, and marine sediments. Actinomycetes are considered a source of bioactive compounds because of their metabolic diversity, and they produce various secondary metabolites that are clinically and commercially important 13) . To identify the molecules that affect cell growth pattern of C. auris, we screened a culture supernatant library of 95 novel actinomycete strains isolated from deep-sea environments that remain relatively unexplored compared with soil actinomycetes [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of <i>Candida auris</i>

Yamane

Niki

Tsubouchi

et al. 2023

Medical Mycology Journal

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The multidrug-resistant pathogen Candida auris is characterized by its aggregation under certain conditions, which affects its biofilm formation, drug susceptibility, and pathogenicity. Although the innate tendency to aggregate depends on the strain, the mechanism regulating C. auris aggregation remains unclear. We found that the culture supernatant from one of the 95 Actinomyces strains isolated from a deep-sea environment (IMAs2016D-66) inhibited C. auris aggregation. The cells grown in the presence of IMAs2016D-66 exhibited reduced hydrophobicity, biofilm formation, and enhanced proteolytic activity. In addition, the efflux pump activity of the fluconazole-resistant C. auris strain LSEM 3673 was stimulated by IMAs2016D-66, whereas no significant change was observed in the fluconazole-susceptible strain LSEM 0643. As the relationship between aggregative tendency and virulence in C. auris is still unclear, IMAs2016D-66 can serve as a tool for investigating regulatory mechanisms of phenotype switching and virulence expression of C. auris. Understanding of phenotype switching may help us not only to understand the pathogenicity of C. auris, but also to design new drugs that target the molecules regulating virulence factors.

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“…Actinomycetes are one of the most widely used biocontrol microorganisms; have great practical value; and are closely associated with human health, agriculture, and biotechnology [ 1 ]. Approximately 8,000 bioactive substances have been discovered in microorganisms, of which approximately 70% are derived from Actinomycetes [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Cyclic Dipeptides and a New Compound (6-(5-Hydroxy-6-methylheptyl)-5,6-dihydro-2H-pyran-2-one) Produced by Streptomyces fungicidicus against Alternaria solani

et al. 2022

Molecules

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As an important microbial resource, Actinomycetes, especially Streptomyces, have important application values in medicine and biotechnology. Streptomyces fungicidicus SYH3 was isolated from soil samples in tomato-growing areas and showed good inhibitory effects on Alternaria solani in tomato. To obtain pure active compounds, SYH3 fermentation broth was subjected to XAD-16 macroporous resin and silica gel column chromatography. Combined with the repeated preparation and separation of preparative high-performance liquid chromatography (HPLC), a total of four monomer compounds were obtained after activity tracking. Compound 4 was identified as a new six-membered lactone ring compound named 6-(5-hydroxy-6-methylheptyl)-5,6-dihydro-2H-pyran-2-one by 1D and 2D nuclear magnetic resonance (NMR) data and mass spectrometry (MS). The other three active compounds belong to the cyclodipeptide, and their half maximal inhibitory concentration (IC50) values against A. solani were 43.4, 42.9, and 30.6 μg/mL, respectively. Compound 4 significantly inhibited the spore germination and induced swollen and deformed local hyphae of A. solani with an IC50 value of 24.9 μg/mL. Compound 4 also had broad-spectrum antifungal activity and had a good antifungal effect on the tested plant-pathogenic fungi. The modes of action of new compound (4) still require further investigation, representing a novel and effective anti-fungal agent for future application.

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Recent Advances of Actinomycetes

Abstract: The discovery and development of actinomycete secondary metabolites (ASMs) have played pivotal roles in the fields of human medicine and its related biotechnology sectors over the past several decades [...]

Cited by 9 publications

References 15 publications

Importância dos metabólitos secundários produzidos por actinobactérias

Importância dos metabólitos secundários produzidos por actinobactérias

A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of <i>Candida auris</i>

Identification of Cyclic Dipeptides and a New Compound (6-(5-Hydroxy-6-methylheptyl)-5,6-dihydro-2H-pyran-2-one) Produced by Streptomyces fungicidicus against Alternaria solani

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