Recent advances of ambient mass spectrometry imaging for biological tissues: A review

Xiao, Yipo; Deng, Jiewei; Yao, Yao; Fang, Ling; Yang, Yunyun; Luan, Tiangang

doi:10.1016/j.aca.2020.01.052

Cited by 53 publications

(39 citation statements)

References 105 publications

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“…Ambient mass spectrometry (AMS) has become increasingly important in the last 15 years thanks to the ability to analyse multiple substances at the level of traces in complex matrices, with little pre-preparation of the sample or even without preparation [9]. AMS allows for fast in-situ analysis and in real time, usually combined with high resolution mass spectrometry.…”

Section: Coupling Of Miniaturised Gas Chromatographs With Mass Spectrometersmentioning

confidence: 99%

Mobile Gas Chromatographs Coupled with Mass and Ion Mobility Spectrometers and their Applications

Witkiewicz

Wardencki

2021

Ecological Chemistry and Engineering S

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Chemical analysis of different materials at the place where analytes are present (on-site analysis) has several advantages in comparison to analysis of these materials after delivering the samples to laboratory. Mobile devices, possessing expected properties in terms of using energy, mass and volume are needed for such analyses. The obtained results should be comparable to those obtained with the stationary instruments. Mass and ion mobility spectrometers are examples of the instruments fulfilling these requirements. At the beginning, the article describes the developments in combining of mass and ion mobility spectrometers (MS, IMS) with miniature gas chromatographs (GC). Both systems are used for analyses in the field, mainly for determination of environmental pollutions. They are used not only for analysis of typical chemicals present in different environmental compartments (in air, water and soil samples) but also for analysis of explosives, drugs and chemical warfare agents when fast results are needed. Particularly noteworthy is their applications in space exploration on the International Space Station. The selected examples of applications of miniaturised GC-MS and GC-IMS devices are presented in the second part of this mini review.

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Section: Coupling Of Miniaturised Gas Chromatographs With Mass Spectrometersmentioning

confidence: 99%

Mobile Gas Chromatographs Coupled with Mass and Ion Mobility Spectrometers and their Applications

Witkiewicz

Wardencki

2021

Ecological Chemistry and Engineering S

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“…Matrix-assisted laser desorption/ionization combined with mass spectrometry (MALDI-MS), while not strictly a SIMS technique, is also often used to image biological samples and is mentioned here for comparison. For more information on MALDI and other mass spectrometry imaging methods, we refer the reader to the following reviews and studies: Hanrieder et al ( 2013 ); Passarelli and Ewing ( 2013 ); Petras et al ( 2017 ); Buchberger et al ( 2018 ); and Xiao et al ( 2020 ).…”

Section: Sims Analysismentioning

confidence: 99%

Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels

Bonnin

Rizzoli

2020

Front. Behav. Neurosci.

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The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically been observed using liquid mass spectrometry methods, averaging the effect of animal behavior across tissue samples containing multiple cells. These methods have provided the scientific community with valuable information, but have limited resolution, making it difficult if not impossible to examine metabolic effects at the cellular and subcellular levels. Recent advances in the field of secondary ion mass spectrometry (SIMS) have made it possible to examine the metabolic effects of animal behavior with high resolution at the nanoscale, enabling the analysis of the metabolic effects of behavior on individual cells. In this review we summarize and present these emerging methods, beginning with an overview of the SIMS technique. We then discuss the specific application of nanoscale SIMS (NanoSIMS) to examine cell behavior. This often requires the use of isotope labeling to highlight specific sections of the cell for analysis, an approach that is presented at length in this review article. We also present SIMS applications concerning animal and cell behavior, from development and aging to changes in the cellular activity programs. We conclude that the emerging group of SIMS technologies represents an exciting set of tools for the study of animal behavior and of its effects on internal metabolism at the smallest possible scales.

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“…In recent years, outstanding progress has been achieved in plant tissue MSI analysis. Technical improvements, including sample preparation [2], ionization technology development [3,4], novel matrices design [5][6][7][8], and single-cell MSI [9,10], have led to wide applications in plants. This review summarises the advances of MSI in plant tissue analysis in the last 5 years, and mainly introduces commonly used ionization techniques, primary technical advances, and recent applications in plant MSI analysis.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry imaging for direct visualization of components in plants tissues

Han

Sheng

et al. 2021

J of Separation Science

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Mass spectrometry is considered the most informative technique for components identification and has been widely adopted in plant sciences. However, the spatial distribution of compounds in the plant, which is vital for the exploration of plant physiological mechanisms, is missed in MS analysis. In recent years, mass spectrometry imaging has brought a great breakthrough in plant analysis because it can determine both the molecular compositions and spatial distributions, which is conducive to understand functions and regulation pathways of specific components in plants. Mass spectrometry imaging analysis of plant tissue is toward high sensitivity, high spatial resolution, and even single-cell analysis. Despite many challenges and technical barriers, such as difficulties of sample pretreatment caused by morphological diversity of plant tissues, obstacles for high spatial resolution imaging, and so on, lots of researches have contributed to remarkable progress, including improvement in tissue preparation, matrix innovation, and ionization mode development. This review focuses on the advances of mass spectrometry imaging analysis of plants in the last 5 years, including commonly used ionization techniques, technical advances, and recent applications of mass spectrometry imaging in plants.

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Recent advances of ambient mass spectrometry imaging for biological tissues: A review

Cited by 53 publications

References 105 publications

Mobile Gas Chromatographs Coupled with Mass and Ion Mobility Spectrometers and their Applications

Mobile Gas Chromatographs Coupled with Mass and Ion Mobility Spectrometers and their Applications

Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels

Mass spectrometry imaging for direct visualization of components in plants tissues

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