Recent advances of anti-cancer therapies including the use of cell-penetrating peptides

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery

“…These excellent results encouraged us to test the potential of the helical responsive MP1 for the transport of antibodies, [5][6][7]40,60,61 which was evaluated with mouse monoclonal Mab414 against the nuclear pore complex proteins ( Fig. 6 and Fig.…”

“…5,39 Nevertheless, most of the recently developed synthetic transporters incorporate a high number of cationic residues and/or show strong amphiphilic character, which can easily destroy membranes and cause toxicity. 6,40 Despite a high number of charges could interfere with anionic biomolecules and cause toxicity, certain reported peptides reduce these limitations by controlling their membranolytic activity, such as RALA, 41 which requires endosomal pH acidification. Despite these clear precedents, little attention has been focused on the development of rational strategies for the design of membrane targeted molecules with selective and transient non-lytic membrane disruption and with a minimum number of cationic and hydrophobic residues.…”

Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets

“…While delivery into target cells or tissue types has not been extensively explored with regards to HIV-1, the use of nanoparticles [92,100,101], liposomes [101][102][103][104], cell-penetrating peptides [105,106], receptor-mediated targeting [107][108][109] and aptamers [110][111][112] have been assessed for use in cell based-therapeutic approaches. Further, results from our lab suggest that lncRNAs can be successfully targeted using either siRNA conjugates [113] or antisense oligonucleotides encapsulated in either nanoparticles or exosomes [114] to potentially mediate positive therapeutic outcomes.…”

Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides

“…The protein also offers the possibility to insert peptides at the N and C-terminus, as well as in a loop containing amino acid residues 59–66, for display on the surface of intact virions or CP assemblies [38]. This latter property is interesting because peptides and in particular cell-penetrating peptides have clear beneficial effects in the context of cancer disease [39,40,41]. Among the different therapeutic approaches in which peptides are used, a recent strategy involves a “membrane-targeting peptide” (MTP) of 30 amino acids that mimics the transmembrane segment of NRP1 (MTP-NRP1).…”