Recent advances of antitumor leading compound Erianin: Mechanisms of action and structural modification

Ma, Lu; Li, Menglong; Zhang, Yueteng; Liu, Kangdong

doi:10.1016/j.ejmech.2023.115844

Cited by 8 publications

(1 citation statement)

References 80 publications

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“…Erianin, a natural product derived from Dendrobium chrysotoxum Lindl 23 , has extensive and potent pharmacological activities, including anti-tumor 68 , anti-inflammatory 69 , and anti-bacterial 20 . Previous studies have demonstrated that Erianin exerted strongly effective anti-tumor effect by promoting apoptosis 21 , ferroptosis 70 , and autophagy 71 , and inhibiting angiogenesis 72 .…”

Section: Discussionmentioning

confidence: 99%

Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells

Han,

Chen,

Wang

et al. 2024

J. Cancer

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Highly activated aerobic glycolysis provides the metabolic requirements for tumor cell growth and proliferation. Erianin, a natural product isolated from Dendrobium chrysotoxum Lindl , has been reported to exert antitumor activity in multiple cancers. However, whether Erianin exerts inhibitory effects on aerobic glycolysis and the inherent mechanism remain poorly defined in non-small cell lung cancer (NSCLC). Here, we showed that Erianin inhibited the cell viability and proliferation, and induced apoptosis in NSCLC cells. Moreover, Erianin overtly suppressed aerobic glycolysis via decreasing HK2 expression. Mechanistically, Erianin dose-dependently curbed the Akt-GSK3β signaling pathway phosphorylation activation, which afterwards downregulated HK2 expression. Meanwhile, Erianin inhibited HCC827 tumor growth in vivo. Taken together, our results suggest that the natural product Erianin can suppress aerobic glycolysis and exert potent anticancer effects via the Akt-GSK3β signaling pathway in NSCLC cells.

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