2023
DOI: 10.3390/pharmaceutics15082093
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Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

Abstract: Peptides and proteins, two important classes of biomacromolecules, play important roles in the biopharmaceuticals field. As compared with traditional drugs based on small molecules, peptide- and protein-based drugs offer several advantages, although most cannot traverse the cell membrane, a natural barrier that prevents biomacromolecules from directly entering cells. However, drug delivery via cell-penetrating peptides (CPPs) is increasingly replacing traditional approaches that mediate biomacromolecular cellu… Show more

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Cited by 11 publications
(4 citation statements)
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“…TAT, oligoarginine, nona-arginine and other CPPs, have been extensively studied to assess their drug delivery capabilities. [35][36][37] Among these, nona-arginine (R 9 ), a well-known synthetic arginine-rich CPP, has been shown to increase transport of cargoes across biological barriers or interfaces. 38,39 Nonetheless, although R 9 can effectively deliver liposomes into tumor cells, it lacks tissue selectivity and therefore penetrates all cell membranes.…”
Section: Introductionmentioning
confidence: 99%
“…TAT, oligoarginine, nona-arginine and other CPPs, have been extensively studied to assess their drug delivery capabilities. [35][36][37] Among these, nona-arginine (R 9 ), a well-known synthetic arginine-rich CPP, has been shown to increase transport of cargoes across biological barriers or interfaces. 38,39 Nonetheless, although R 9 can effectively deliver liposomes into tumor cells, it lacks tissue selectivity and therefore penetrates all cell membranes.…”
Section: Introductionmentioning
confidence: 99%
“…Crotamine, which is a protein isolated from Crotalus durissus terrificus, has different positive biological effects; when injected in the hippocampus, crotamine has been shown to improve cognition in rats . Additionally, this polypeptide possesses cell-penetrating properties, which can play a role in drug delivery. , For years, many cell-penetrating peptides have been studied for AD treatment due to their nontoxic and high activity properties. Crotamine has two specific regions that enable it to translocate quickly and efficiently into actively proliferating cells .…”
Section: Introductionmentioning
confidence: 99%
“…24 Additionally, this polypeptide possesses cell-penetrating properties, which can play a role in drug delivery. 25,26 For years, many cell-penetrating peptides have been studied for AD treatment due to their nontoxic and high activity properties. Crotamine has two specific regions that enable it to translocate quickly and efficiently into actively proliferating cells.…”
Section: ■ Introductionmentioning
confidence: 99%
“…Thirdly, proteins have great potential in the field of personalized medicine, since molecular biology makes it possible to create protein molecules that best suit the individual needs and characteristics of the patient. It is already clear that in the future protein drugs will have many new opportunities and prospects in the field of medicine [10][11][12][13]. For example, a new class of pharmaceutical protein drugs based on gradual technology has recently emerged [14].…”
Section: Introductionmentioning
confidence: 99%