Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications

Liu, Xinhua; Cheng, Zheng; Luo, Xiaomin; Wang, Xuechuan; Jiang, Huie

doi:10.1016/j.msec.2019.02.070

Cited by 227 publications

(163 citation statements)

References 93 publications

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“…(Li and Nabet, 2019). In order to increase the efficiency of soft tissue defect correction, ATT is complemented with ADSCs (Liefhebber et al, 2010;Liu et al, 2019). Additionally, MSC-like cells can be applied in tumor-targeted cell therapy (Paino et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression

Wang

Chu

et al. 2020

Front. Cell Dev. Biol.

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Objectives: Homosapien collagen beta (1-O) galactosyl transferase 2 (COLGALT2) is an important enzyme during collagen glycosylation, yet its biological functions in cancer are incompletely understood. Our previous study revealed that in the osteosarcoma microenvironment, adipose-derived mesenchymal stem cells (ADSCs) demonstrate cancer-promoting effects, but the exact mechanisms remain unclear. The aim of this study was to investigate the role of COLGALT2 in the osteosarcoma-fostering effects of ADSCs. Materials and Methods: In this study, we compared COLGALT2 expression between primary and metastatic osteosarcoma tissues and found that metastatic tissues expressed significantly higher COLGALT2 levels. Then, we isolated and identified exosomes secreted by ADSCs. Additionally, we assessed the roles of ADSC exosomes and COLGALT2 in the osteosarcoma-promoting effects of ADSCs. Results: Our results showed that ADSC exosomes could foster the invasion, migration, and proliferation of osteosarcoma cells, together with increasing COLGALT2 expression. COLGALT2 inhibition in MG63 cells suppressed the ADSC exosomemediated fostering of osteosarcoma cell invasion, migration and proliferation in vitro. Conversely, COLGALT2 overexpression promoted U-2OS cell invasion, migration and proliferation in vitro. Additionally, COLGALT2 inhibition attenuated metastasis and tumor growth, and ADSC exosomes promoted tumor progression, as demonstrated in a nude mouse model of osteosarcoma. Conclusion: According to these data, ADSC exosomes foster osteosarcoma progression by increasing COLGALT2 expression in osteosarcoma cells.

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Section: Discussionmentioning

confidence: 99%

Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression

Wang

Chu

et al. 2020

Front. Cell Dev. Biol.

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“…[21]. Because of its good biocompatibility, biodegradability and bioactivity, it has been widely used in food, medicine, tissue engineering and other fields [62]. Commercial collagen-based nerve conduits such as NeuroMatrix ® , Neuroflex ® (Collagen Matrix Inc. Oakland, NJ, USA) and NeuraGen ® (Integra Lifesciences Corp. Princeton, NJ, USA) have been approved by the FDA [79].…”

Section: Printable Hydrogelsmentioning

confidence: 99%

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Zhang

2020

Polymers

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Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.

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“…As α1 contem 1055 resíduos de aminoácidos enquanto a α2 apresenta 1029 resíduos, sendo esses resíduos formados em grande parte por glicina (Gly), prolina (Pro) e hidroxiprolina. (Yu et al, 2015 (Smith, 1968;Liu et al, 2019;Yu et al, 2015).…”

Section: Colágeno Tipo Iunclassified

“…A zona com cinco moléculas de tropocolágeno é denominada de zona ''Overlap'', e a zona onde há quatro moléculas é denominada de zona ''Gap''. Esse modelo de Smith também é conhecido como modelo 'quarto alternado pentafibrilar', sendo que cada período D apresenta de 64 a 67 nm de largura e de 30 a 35 nm de diâmetro (Jastrzebska et al, 2017;Liu et al, 2019). O tropocolágeno e o modelo de Smith são representados na Figura 4.…”

Section: Colágeno Tipo Iunclassified

“…O colágeno também possui a capacidade de induzir e orientar a formação de novos tecidos em caso de lesão. A exposição de colágeno, que inicia o processo de hemostasia, também desencadeia cascatas químicas e fatores bioquímicos que auxiliam na reparação tecido mole como pele e músculos e tecido duro como ossos e dentes (Cen et al, 2008;Moussa et al, 2018;Liu et al, 2019). (Canevarolo, 2002).…”

Section: Colágeno Tipo Iunclassified

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Desenvolvimento de matrizes de colágeno/nanohidroxiapatita contendo extratos vegetais para regeneração óssea

Garcia¹

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Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications

Cited by 227 publications

References 93 publications

Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression

Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Desenvolvimento de matrizes de colágeno/nanohidroxiapatita contendo extratos vegetais para regeneração óssea

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