Recent Advances of Endoscopy in Inflammatory Bowel Diseases

Cheon, Jae Hee; Kim, Jae Hak

doi:10.5009/gnl.2007.1.2.118

Cited by 30 publications

(26 citation statements)

References 61 publications

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“…The difference can likely be explained as being secondary to early diagnosis and treatment of intestinal BD, possibly through widely available colonoscopies and advanced medical knowledge. 17 In studies of intestinal BD patients undergoing medical treatment, Chung et al 18 demonstrated that the cumulative recurrence rates in nonsurgical patients were 24.9% at 2 years and 43.0% at 5 years. Furthermore, Choi et al 15 reported that recurrence rates were 25% at 2 years and 49% at 5 years after complete remission via medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Jung

Yoon

Lee

et al. 2011

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 99%

Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Jung

Yoon

Lee

et al. 2011

Inflammatory Bowel Diseases

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“…Complete medical records were reviewed to confirm the diagnosis of UC. The diagnosis of UC was based on accepted clinical, endoscopic, histological, and radiological criteria supported by histopathology [10,11]. These criteria are: (1) a typical history of diarrhea, hematochezia, or both for longer than 1 month; (2) typical endoscopic or radiologic findings such as continuous ulcerative mucosa with granularity and friability without skip lesions, and (3) characteristic histopathological signs of inflammation on biopsy.…”

Section: Methodsmentioning

confidence: 99%

Do Patients with Ulcerative Colitis Diagnosed at a Young Age Have More Severe Disease Activity than Patients Diagnosed when Older?

et al. 2010

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Background/Aims: To compare the clinical features and disease behavior of ulcerative colitis (UC) according to the age at onset. Methods: This retrospective study included 455 patients with UC who were diagnosed and treated between 1990 and 2008 at a single tertiary institution in Korea. The patients were divided into 2 groups according to their age at diagnosis of UC: an elderly group (≧40 years) and a young group (<40 years). Clinical findings at diagnosis, extent of disease, treatment modalities used, cumulative admission rates, cumulative relapse rates, and surgery rates were analyzed according to these age groups. Results: Two hundred and forty-two patients with UC (53.2%) were diagnosed before the age of 40 years. Disease severity at initial presentation as assessed by diarrhea frequency, the presence of pancolitis, and the use of steroids were higher in the young group; however, clinical disease course including cumulative admission rates, cumulative relapse rates, and surgery rates were not significantly different between the 2 groups. Conclusions: Certain clinical features and the extent of disease in UC patients appear to be more severe when the disease is diagnosed at younger age; however, their disease course and prognosis might not be different from those of their older counterparts.

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“…It illuminates the tissue surface through special filters that narrow the red, green and blue bands with increased intensity of the blue band to enhance the tissue microvascular structure as a result of the differential optical absorption of light by hemoglobin [30] .…”

Section: New Endoscopic Techniquesmentioning

confidence: 99%

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

Lukáš¹

2010

Dig Dis

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Patients with long-term inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn’s colonic disease (CD) have an increased risk of colorectal carcinoma (CRC). Eaden’s meta-analysis has shown that the risk for CRC in UC patients is 2% at 10 years, 8% at 20 years and 18% at 30 years of disease duration. It is now accepted that the risk of colorectal cancer is equivalent in both (UC and CD) conditions. Duration of disease is recognized to be the most important risk factor for CRC development. Extent of disease in another major risk factor. Most cancers arise in patients with extensive disease, which is generally defined as extension of inflammation beyond the hepatic flexure. It was demonstrated that proctitis and proctosigmoiditis posed no increased risk for patients with UC. Recent data from case control studies suggests that greater degrees of colonoscopic or histologically active inflammation are associated with an increased risk of CRC. Recently, it has been proven that shortened tubular colon, colonic stricture and postinflammatory polyps should be considered strong risk factors for CRC development. Primary sclerosing cholangitis (PSC) in patients with UC is associated with substantial risk of CRC. Screening colonoscopy should be performed in patients with UC after 8–10 years of disease. The interval between surveillance examinations is dependent on each individual’s personal risk factors. In patients with a previous history of PSC, ongoing active inflammation, previous history of dysplasia or strictures, and strong family history of bowel cancer, annual surveillance is recommended. Colectomy is strictly recommended for patients who were diagnosed with flat high-grade dysplasia (HGD) or CRC and where the diagnosis was confirmed by expert gastrointestinal pathologists. In patients with a biopsy specimen considered indefinite for dysplasia, guidelines suggest colonoscopy between 3 and 12 months. Multifocal low-grade dysplasia (LGD) is a stronger indication for colectomy. The optimal colonoscopic surveillance interval for patients who were diagnosed with a flat LGD is still unknown, but 3–6 months is often recommended. Chemopreventive agents should be used to minimize the risk of developing dysplasia or CRC in IBD patients. It has been shown that mesalazine has a preventive effect for CRC and dysplasia.

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Recent Advances of Endoscopy in Inflammatory Bowel Diseases

Cited by 30 publications

References 61 publications

Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Do Patients with Ulcerative Colitis Diagnosed at a Young Age Have More Severe Disease Activity than Patients Diagnosed when Older?

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

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