Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications

Xue, Yulun; Riva, Nicoletta; Zhao, Lingying; Shieh, Ju-sheng; Chin, Yu-Tang; Gatt, Alexander; Guo, Jiong Jiong

doi:10.1016/j.jconrel.2023.10.031

Cited by 8 publications

(4 citation statements)

References 177 publications

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“…At the same time, exosome uptake is an important step in intercellular cargo transportation. The uptake of exosomes by recipient cells occurs mainly through endocytosis, phagocytosis, or direct fusion with the plasma membrane (24)(25)(26). Exocytosis can be categorized into lattice protein-mediated exocytosis, lipid raft-mediated exocytosis, and heparan sulfate proteoglycan-dependent exocytosis.…”

Section: The Biogenesis and Isolation Of Exosomesmentioning

confidence: 99%

Engineered exosomes in emerging cell-free therapy

Si,

Gao,

2024

Front. Oncol.

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The discovery and use of exosomes ushered in a new era of cell-free therapy. Exosomes are a subgroup of extracellular vesicles that show great potential in disease treatment. Engineered exosomes. with their improved functions have attracted intense interests of their application in translational medicine research. However, the technology of engineering exosomes still faces many challenges which have been the great limitation for their clinical application. This review summarizes the current status of research on engineered exosomes and the difficulties encountered in recent years, with a view to providing new approaches and ideas for future exosome modification and new drug development.

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Section: The Biogenesis and Isolation Of Exosomesmentioning

confidence: 99%

Engineered exosomes in emerging cell-free therapy

Si,

Gao,

2024

Front. Oncol.

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“…The regenerative signals carried by exosomes can influence the behavior of cells involved in tissue healing. [27] Exosomes have been shown to have anti-inflammatory effects, modulating the immune response. In sports medicine, this property is relevant for managing inflammation associated with injuries or overexertion.…”

Section: Role Of Exosomes In Sports Medicinementioning

confidence: 99%

Exosomes - breakthrough in the regenerative medicine and a way to improve the quality of the life

Brzozowska,

Maj-Dziedzic,

Sikora

et al. 2024

J Educ Health Sport

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Introduction Exosomes are small, membrane-bound extracellular vesicles that play a pivotal role in intercellular communication. Exosomes have garnered significant interest in regenerative medicine due to their unique properties that support tissue repair, regeneration, and healing. These extracellular vesicles play a crucial role in intercellular communication, and their regenerative potential makes them promising tools in the field of regenerative medicine. Purpose of the study This review aims to present the regenerative properties of exosomes and their clinical applications in many fields of medicine. The main aim is to present exosomes as a substance that restores health, youth and vitality. Material and method Literature review was primarily based on scientific materials, English and Polish databases and original research. The following English keywords and its Polish equivalents were used to search Google Scholar and PubMed: “ exosomes", “regenerative medicine”, “stem cells”.

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“…Prior to the reports of good versus poor outcomes following natural healing of the AT, and continuing to today, many studies have attempted to improve healing using a variety of interventions without attempting to segregate naturally occurring good and poor healers. While not all of the interventions have assessed efficacy for AT healing, the interventions utilized include growth factors [reviewed in (El-Sherif et al, 2023;Lin et al, 2023;Miescher et al, 2023;Rieber et al, 2023;Wang and Li, 2023)], acupuncture (Stewman, 2023), platelet-rich plasma (PRP) and variations (Markazi et al, 2022;Everts et al, 2023), other cell therapies including mesenchymal stem cells (MSC) (Chamberlain et al, 2017;Alt et al, 2021;Zhang et al, 2021;Jiang L. et al, 2023;Yuan et al, 2023;Zulkifli et al, 2023), and extracellular vesicles (EV) derived from MSC and related stem cells (Lu et al, 2021;Lyu et al, 2022;Wang and Li, 2023;Xue et al, 2023;Zou et al, 2023) and other cellular preparations (Aydin et al, 2023). Use of glucocorticoid injections to ostensibly control inflammation to enhance tendon healing or improve the local injury environment was variable and dependent on a variety of factors (Dietrich-Zagonel et al, 2018;Dietrich-Zagonel et al, 2022), and was often detrimental to healing (Dean et al, 2014).…”

Section: Attempts To Improve Outcomes After a Tendon Injury: Focusing...mentioning

confidence: 99%

Optimizing tendon repair and regeneration: how does the in vivo environment shape outcomes following rupture of a tendon such as the Achilles tendon?

Hart,

Ahmed,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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Risk for rupture of the Achilles tendon, and other tendons increases with age. Such injuries of tissues that function in high load environments generally are believed to heal with variable outcome. However, in many cases, the healing does not lead to a good outcome and the patient cannot return to the previous level of participation in active living activities, including sports. In the past few years, using proteomic approaches and other biological techniques, reports have appeared that identify biomarkers that are prognostic of good outcomes from healing, and others that are destined for poor outcomes using validated criteria at 1-year post injury. This review will discuss some of these recent findings and their potential implications for improving outcomes following connective tissue injuries, as well as implications for how clinical research and clinical trials may be conducted in the future where the goal is to assess the impact of specific interventions on the healing process, as well as focusing the emphasis on regeneration and not just repair.

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Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications

Cited by 8 publications

References 177 publications

Engineered exosomes in emerging cell-free therapy

Engineered exosomes in emerging cell-free therapy

Exosomes - breakthrough in the regenerative medicine and a way to improve the quality of the life

Optimizing tendon repair and regeneration: how does the in vivo environment shape outcomes following rupture of a tendon such as the Achilles tendon?

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