Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications

Chen, Weipeng; Liu, Miao; Yang, Hanping; Nezamzadeh‐Ejhieh, Alireza; Lu, Chengyu; Pan, Ying; Liu, Jian Qiang; Bai, Zhi

doi:10.3390/pharmaceutics15051323

Cited by 27 publications

(4 citation statements)

References 145 publications

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“…Polyphenols and metal ions readily dissociate at low pH, enabling the controlled release of a metal ion, with Fe being the most common metal. MPNs have great potential in chemotherapy, as they can produce highly toxic hydroxyl radicals (•OH) that effectively help the drug kill tumor cells [ 123 ].…”

Section: Other Hybrid Networkmentioning

confidence: 99%

Synthesis and Applications of Hybrid Polymer Networks Based on Renewable Natural Macromolecules

Getya

Gitsov

2023

Molecules

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Macromolecules obtained from renewable natural sources are gaining increasing attention as components for a vast variety of sustainable polymer-based materials. Natural raw materials can facilitate continuous-flow production due to their year-round availability and short replenishment period. They also open new opportunities for chemists and biologists to design and create “bioreplacement” and “bioadvantaged” polymers, where complex structures produced by nature are being modified, upgraded, and utilized to create novel materials. Bio-based macromonomers are expected not only to compete with but to replace some petroleum-based analogs, as well. The development of novel sustainable materials is an ongoing and very dynamic process. There are multiple strategies for transforming natural macromolecules into sophisticated value-added products. Some methods include chemical modification of macromolecules, while others include blending several components into one new system. One of the most promising approaches for incorporating renewable macromolecules into new products is the synthesis of hybrid networks based on one or more natural components. Each one has unique characteristics, so its incorporation into a network brings new sustainable materials with properties that can be tuned according to their end-use. This article reviews the current state-of-the-art and future potential of renewable natural macromolecules as sustainable building blocks for the synthesis and use of hybrid polymer networks. The most recent advancements and applications that involve polymers, such as cellulose, chitin, alginic acid, gellan gum, lignin, and their derivatives, are discussed.

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Section: Other Hybrid Networkmentioning

confidence: 99%

Synthesis and Applications of Hybrid Polymer Networks Based on Renewable Natural Macromolecules

Getya

Gitsov

2023

Molecules

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“…9 As a new class of iron-based material, iron-based sulfides have attracted a lot of attention due to usage in biomedical applications, especially as nanomaterials. 10 Iron sulfide was shown to be more effective than ferrous ions at catalyzing the hydroxyl radical synthesis from hydrogen peroxide. [11][12][13] Moreover, the degraded nanoparticles have produced a relatively high concentration of exogenous H 2 S that causes mitochondrial and cellular cycle disruption of the cancer cells in the normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and cytotoxicity of greigite nanoparticles synthesized by hydrothermal technique

Naser,

Lafta,

Hashim

2024

Biotech and App Biochem

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The effects of 180, 210, and 230°C reaction temperatures on the structural and magnetic properties of synthesized iron sulfide nanoparticles were studied. The Rietveld refinement analysis result of the X‐ray diffraction data indicated that greigite was the dominant phase in all samples. The sample was prepared at 210°C for 18 h and had a greater wt% ratio of the greigite phase. The crystallite and particle sizes increased with increasing reaction temperatures. Scanning electron microscope images confirmed the presence of aggregation of synthesized rod‐shaped nanoparticles. The magnetic hysteresis curves of all samples showed ferromagnetic behavior at room temperature. The magnetic saturation of three samples increases with increased reaction temperature, but the coercive force has the opposite behavior. Antioxidant activity and cytotoxicity of the sample synthesized at 210°C were investigated. This sample killed cancer cells at relatively moderate and high concentrations with high viability of normal cells, demonstrating the sample's suitability for use in killing cancer cells while avoiding normal cells.

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“…Recently, extensive research showed that iron-based metal-phenolic networks (MPNs) have great potential for drug delivery and cancer therapy [ 19 , 20 , 21 , 22 , 23 ]. The contained polyphenols provide interaction points for hydrogen and covalent bond formation, π–π stacking, hydrophobic interactions, and metal coordination [ 20 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Iron-Gallic Acid Peptide Nanoparticles as a Versatile Platform for Cellular Delivery with Synergistic ROS Enhancement Effect

et al. 2023

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Cytosolic delivery of peptides is of great interest owing to their biological functions, which could be utilized for therapeutic applications. However, their susceptibility to enzymatic degradation and multiple cellular barriers generally hinders their clinical application. Integration into nanoparticles, which can enhance the stability and membrane permeability of bioactive peptides, is a promising strategy to overcome extracellular and intracellular obstacles. Herein, we present a versatile platform for the cellular delivery of various cargo peptides by integration into metallo-peptidic coordination nanoparticles. Both termini of cargo peptides were conjugated with gallic acid (GA) to assemble GA-modified peptides into nanostructures upon coordination of Fe(III). Initial pre-complexation of Fe(III) by poly-(vinylpolypyrrolidon) (PVP) as a template favored the formation of nanoparticles, which are able to deliver the peptides into cells efficiently. Iron–gallic acid peptide nanoparticles (IGPNs) are stable in water and are supposed to generate reactive oxygen species (ROS) from endogenous H2O2 in cells via the Fenton reaction. The strategy was successfully applied to an exemplary set of peptide sequences varying in length (1–7 amino acids) and charge (negative, neutral, positive). To confirm the capability of transporting bioactive cargos into cells, pro-apoptotic peptides were integrated into IGPNs, which demonstrated potent killing of human cervix carcinoma HeLa and murine neuroblastoma N2a cells at a 10 µM peptide concentration via the complementary mechanisms of peptide-triggered apoptosis and Fe(III)-mediated ROS generation. This study demonstrates the establishment of IGPNs as a novel and versatile platform for the assembly of peptides into nanoparticles, which can be used for cellular delivery of bioactive peptides combined with intrinsic ROS generation.

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Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications

Cited by 27 publications

References 145 publications

Synthesis and Applications of Hybrid Polymer Networks Based on Renewable Natural Macromolecules

Synthesis and Applications of Hybrid Polymer Networks Based on Renewable Natural Macromolecules

Antioxidant activity and cytotoxicity of greigite nanoparticles synthesized by hydrothermal technique

Iron-Gallic Acid Peptide Nanoparticles as a Versatile Platform for Cellular Delivery with Synergistic ROS Enhancement Effect

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