Recent advances of hydrogels as smart dressings for diabetic wounds

Abstract

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy of diabetic wounds.

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

“…However, they have no direct effect on wound healing, and their limited ability to absorb exudate increases the frequency of change, leading to secondary wound injury. 95 Therefore, medical wound dressings are constantly being improved toward ideal dressings with good absorbency, no contaminant residue, thermal insulation, antimicrobial properties, avoidance of secondary trauma on removal, low frequency of dressing changes required, pain relief and comfort. 96 The fourth is surgical debridement, which is an important part of the treatment of diabetic wounds that facilitates wound recovery by removing necrotic tissue and reducing the extent of local infection.…”

“…The third is traditional dressings, including dry gauze, oil gauze, cotton pads, bandages, etc., that play the role of passive protective dressings and are mainly used to isolate wounds. However, they have no direct effect on wound healing, and their limited ability to absorb exudate increases the frequency of change, leading to secondary wound injury . Therefore, medical wound dressings are constantly being improved toward ideal dressings with good absorbency, no contaminant residue, thermal insulation, antimicrobial properties, avoidance of secondary trauma on removal, low frequency of dressing changes required, pain relief and comfort .…”

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

“…As an emerging wound dressing, hydrogels have attracted extensive attention due to their good biological safety and wound adaptability. 23–26 Hydrogels not only promote wound healing by creating a moist environment and absorbing excess exudate, but also serve as a functional drug delivery vehicle for the treatment of wound infections. 27–30 Bacteria usually produce lactic and acetic acids during growth and metabolism in infected wounds, resulting in an acidic environment at the wound site.…”

Screening of Short-Chain Antimicrobial Peptide LKARI with Broad-Spectrum Bactericidal Properties and Its Application in Promoting Wound Healing

“…Soft and elastic, it can relieve pain. The breathing and bacteriostatic nature helps in decreasing the occurrence of wound infection. , Over the past few years, research on wound dressings has focused on transparent wound observation and the creation of an appropriate moist environment to promote healing. ,, The PVA-based hydrogel exhibits exceptional toughness, as stated in research studies. , SA possesses hemostatic properties that can be easily removed. , …”