2021
DOI: 10.1002/cplu.202100030
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Recent Advances of In‐Source Electrochemical Mass Spectrometry

Abstract: Hyphenation of electrochemistry (EC) and mass spectrometry has become a powerful tool to study redox processes. Approaches that can achieve this hyphenation include integrating chromatography/electrophoresis between electroinduced redox reactions and detection of products, coupling an EC flow cell to a mass spectrometer, and performing electrochemical reactions inside the ion source of a mass spectrometer. The first two approaches have been well reviewed elsewhere. This Minireview highlights the inherent elect… Show more

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Cited by 24 publications
(21 citation statements)
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References 117 publications
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“…In the mentioned hyphenation, MS is being used because of its high sensitivity and specificity, providing structural information unavailable from EC methods. Here electrochemical reactions are used to oxidize or reduce analytes to improve the ionization of analytes for MS analysis [4].…”
Section: Introductionmentioning
confidence: 99%
“…In the mentioned hyphenation, MS is being used because of its high sensitivity and specificity, providing structural information unavailable from EC methods. Here electrochemical reactions are used to oxidize or reduce analytes to improve the ionization of analytes for MS analysis [4].…”
Section: Introductionmentioning
confidence: 99%
“…Electrochemical mass spectrometry (EC-MS) is a powerful hyphenated technique to elucidate reaction mechanisms by identifying the products and intermediates in complicated EC reactions. Currently, the most common EC-MS methods applied in water oxidation studies are differential electrochemical mass spectrometry (DEMS) and online electrochemical mass spectrometry (OLEMS). , They have been employed to interpret the oxygen evolution process and the decomposition of molecular catalysts by respectively in situ detecting gaseous products O 2 and CO 2 . However, it is hard for them to obtain information on intermediates in electrochemical water oxidation.…”
mentioning
confidence: 99%
“…Electrochemistry uses electrons as “traceless” reagents instead of the generally used oxidants or reductants to achieve redox reactions and therefore is regarded as an efficient and green synthetic method . Electrochemical reactions of biomolecules have been used to enhance mass spectrometry (MS) analysis of less ionizable molecules, characterize biomolecular structures/substructures, profile redox-active metabolites, and simulate the oxidative metabolism of drugs. For example, the electrochemical reduction of disulfide bonds in cross-linkers (e.g., dithiobis­(succinimidyl propionate), DSP) was used to identify cross-linked peptides and elucidate protein three-dimensional structures . Since biomolecules such as proteins and lipids commonly contain one or more unique structural features that are highly related to their functions, multiple steps of the reactions for probing structural units are needed to achieve complete structural characterization. …”
mentioning
confidence: 99%