Recent Advances of Material‐Decorated Photosynthetic Microorganisms and Their Aspects in Biomedical Applications

Liu, Songhan; Yang, Huiling; Ho, Ming Yao; Xing, Bengang

doi:10.1002/adom.202203038

Cited by 7 publications

(1 citation statement)

References 137 publications

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“…Oxygen has been widely described as a critical molecule in wound healing due to its major role in key processes including cell metabolism, collagen deposition, epithelialization, angiogenesis, and immune response (Guo & Dipietro, 2010; Han & Ceilley, 2017). Therefore, several studies have addressed the need for local oxygen supply (Kimmel et al, 2016; Liu et al, 2023; Tejada et al, 2019). Consequently, various approaches have been explored to promote wound healing by developing oxygen‐releasing biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study

González‐Itier,

Miranda,

Corrales‐Orovio

et al. 2024

Biotech & Bioengineering

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Oxygen is essential for tissue regeneration, playing a crucial role in several processes, including cell metabolism and immune response. Therefore, the delivery of oxygen to wounds is an active field of research, and recent studies have highlighted the potential use of photosynthetic biomaterials as alternative oxygenation approach. However, while plants have traditionally been used to enhance tissue regeneration, their potential to produce and deliver local oxygen to wounds has not yet been explored. Hence, in this work we studied the oxygen‐releasing capacity of Marchantia polymorpha explants, showing their capacity to release oxygen under different illumination settings and temperatures. Moreover, co‐culture experiments revealed that the presence of these explants had no adverse effects on the viability and morphology of fibroblasts in vitro, nor on the viability of zebrafish larvae in vivo. Furthermore, oxygraphy assays demonstrate that these explants could fulfill the oxygen metabolic requirements of zebrafish larvae and freshly isolated skin biopsies ex vivo. Finally, the biocompatibility of explants was confirmed through a human skin irritation test conducted in healthy volunteers following the ISO‐10993‐10‐2010. This proof‐of‐concept study provides valuable scientific insights, proposing the potential use of freshly isolated plants as biocompatible low‐cost oxygen delivery systems for wound healing and tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study

González‐Itier,

Miranda,

Corrales‐Orovio

et al. 2024

Biotech & Bioengineering

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Development of a Hibernation‐Inspired Preservation Strategy to Enhance the Clinical Translation of Photosynthetic Biomaterials

Corrales‐Orovio,

Castillo,

Rozas

et al. 2023

Advanced Therapeutics

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Photosynthetic biomaterials have emerged as a promising approach for delivering oxygen and other bioactive molecules in several biomedical applications. This technology is based on the use of standard biomaterials loaded with photosynthetic cells for the controlled release of oxygen at the target site. However, as well as for other cell‐based approaches, a main drawback for their clinical translation is the low shelf‐life of living materials. In the present study, the potential of inducing a dormant hibernation‐inspired state to preserve photosynthetic biomaterials for clinical applications is explored. First, a protocol to preserve microalgae Chlamydomonas reinhardtii is optimized and then applied to photosynthetic scaffolds, showing that the viability and functionality of the biomaterial is preserved for up to six weeks. To evaluate the clinical viability of this approach, both fresh and preserved photosynthetic scaffolds are implanted in a full‐skin defect mouse model. The safety of this approach is evaluated and confirmed by several means, including clinical parameters, histological assays, and local and systemic molecular analysis. Altogether, this work describes for the first time the successful preservation of photosynthetic biomaterials through a hibernation‐inspired strategy, which could have a tremendous impact for the clinical translation of these materials as well as other photosynthetic therapies.This article is protected by copyright. All rights reserved

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Nature‐Inspired Thylakoid‐Based Photosynthetic Nanoarchitectures for Biomedical Applications

Kong,

Zhu,

et al. 2023

Small Methods

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Abstract“Drawing inspiration from nature” offers a wealth of creative possibilities for designing cutting‐edge materials with improved properties and performance. Nature‐inspired thylakoid‐based nanoarchitectures, seamlessly integrate the inherent structures and functions of natural components with the diverse and controllable characteristics of nanotechnology. These innovative biomaterials have garnered significant attention for their potential in various biomedical applications. Thylakoids possess fundamental traits such as light harvesting, oxygen evolution, and photosynthesis. Through the integration of artificially fabricated nanostructures with distinct physical and chemical properties, novel photosynthetic nanoarchitectures can be catalytically generated, offering versatile functionalities for diverse biomedical applications. In this article, an overview of the properties and extraction methods of thylakoids are provided. Additionally, the recent advancements in the design, preparation, functions, and biomedical applications of a range of thylakoid‐based photosynthetic nanoarchitectures are reviewed. Finally, the foreseeable challenges and future prospects in this field is discussed.

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Recent Advances of Material‐Decorated Photosynthetic Microorganisms and Their Aspects in Biomedical Applications

Cited by 7 publications

References 137 publications

Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study

Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study

Development of a Hibernation‐Inspired Preservation Strategy to Enhance the Clinical Translation of Photosynthetic Biomaterials

Nature‐Inspired Thylakoid‐Based Photosynthetic Nanoarchitectures for Biomedical Applications

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