Recent advances of nanotechnology in the treatment and diagnosis of polycystic ovary syndrome

Naderi, Mohammad Javad Javid; Mahmoudi, Alireza; Kesharwani, Prashant; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1016/j.jddst.2022.104014

Cited by 8 publications

(5 citation statements)

References 74 publications

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“…122 Graphene oxide's efficient drug loading and surface modifications enhance its biocompatibility, 123 while quantum dots offer dual functionality for imaging and targeted drug delivery. 124 Hydrogels, 125 dendrimers, 126 carbon nanotubes, 127 scaffolds, 128 and gold nanoparticles 129 contribute to controlled release, precise drug loading, and enhanced treatment efficacy in reproductive disorders in females, each chosen based on specific therapeutic requirements and characteristics of the targeted condition.…”

Section: Applications Of Nanotechnology-mediated Drug Delivery System...mentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

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Section: Applications Of Nanotechnology-mediated Drug Delivery System...mentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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show abstract

“…One study using a CS/copper-NPs/Fe3O4-NPs/GrO-NPs nanocomposite in the fabrication of a SHBG immunosensor demonstrated the improved efficacy of the immunosensor's analytic performance and detection of SHBG [36]. Therefore, the use of nanomaterials is a robust choice for the detection of SHBG for early diagnosis of PCOS as it is faster, cheaper, and more sensitive and specific than other traditional methods [86].…”

Section: Nanomedicine For Pcos Diagnosismentioning

confidence: 99%

“…While standard practices may be limited, there have been recent advances in nanotechnology for treating PCOS. Recent exploration of innovative therapeutic options for PCOS has included nanoparticles such as silver and selenium, lipid-based nanocarriers, and many herbal-based nanosystems, either alone or in combination with other drugs [86]. Silver nanoparticles synthesized from Cinnamomum zeylanicum are useful in treating inflammation and have shown efficacy in lowering inflammatory markers in rats with PCOS [37].…”

Section: Nanomedicine For Pcos Treatmentmentioning

confidence: 99%

“…Curcumin has demonstrated potential in reducing hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance in those with PCOS [88], but it has limited use due to its solubility and poor body pH availability [88]. However, the bio-compatible nano-curcumin has increased polarity, improved oral absorption, amplified bioavailability, and increased potential for bodily absorption, which could only further improve the symptoms associated with PCOS [86]. In fact, Raja et al found success fabricating nanoparticles containing curcumin-encapsulated arginine and N-acetyl histidine-modified chitosan (CS) nanoparticles, which showed increased cellular uptake in in vitro PCOS models [11].…”

Section: Nanomedicine For Pcos Treatmentmentioning

confidence: 99%

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The Role of Nanomedicine in Benign Gynecologic Disorders

Lulseged,

Ramaiyer,

Michel

et al. 2024

Molecules

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Nanomedicine has revolutionized drug delivery in the last two decades. Nanoparticles appear to be a promising drug delivery platform in the treatment of various gynecological disorders including uterine leiomyoma, endometriosis, polycystic ovarian syndrome (PCOS), and menopause. Nanoparticles are tiny (mean size < 1000 nm), biodegradable, biocompatible, non-toxic, safe, and relatively inexpensive materials commonly used in imaging and the drug delivery of various therapeutics, such as chemotherapeutics, small molecule inhibitors, immune mediators, protein peptides and non-coding RNA. We performed a literature review of published studies to examine the role of nanoparticles in treating uterine leiomyoma, endometriosis, PCOS, and menopause. In uterine leiomyoma, nanoparticles containing 2-methoxyestradiole and simvastatin, promising uterine fibroid treatments, have been effective in significantly inhibiting tumor growth compared to controls in in vivo mouse models with patient-derived leiomyoma xenografts. Nanoparticles have also shown efficacy in delivering magnetic hyperthermia to ablate endometriotic tissue. Moreover, nanoparticles can be used to deliver hormones and have shown efficacy as a mechanism for transdermal hormone replacement therapy in individuals with menopause. In this review, we aim to summarize research findings and report the efficacy of nanoparticles and nanotherapeutics in the treatment of various benign gynecologic conditions.

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“…Furthermore, it has been utilized for aid in the prevention, diagnosis, and treatment of ovulatory disorders. Intriguing characteristics and abilities of nanomaterials include their capacity to attain desirable sizes, to cross biological barriers more quickly, to be more soluble, and to be more reactive [21]. Clomiphene citrate as a nanomedicine possesses and exhibits the below-described benefits.…”

Section: Clomiphene Citrate Nanomedicine Assistancementioning

confidence: 99%

Clomiphene Citrate as Nanomedicine Assistance in Ovulatory Disorders and Its Hyphenated Techniques

et al. 2023

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Recent advances of nanotechnology in the treatment and diagnosis of polycystic ovary syndrome

Cited by 8 publications

References 74 publications

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

The Role of Nanomedicine in Benign Gynecologic Disorders

Clomiphene Citrate as Nanomedicine Assistance in Ovulatory Disorders and Its Hyphenated Techniques

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