Recent advances of online coupling of sample preparation techniques with ultra high performance liquid chromatography and supercritical fluid chromatography

Abstract

Ultra high performance liquid chromatography and supercritical fluid chromatography techniques are favored because of their high efficiency and fast analysis speed. Although many sample preparation techniques have been coupled with common liquid chromatography online, the online coupling of sample preparation with the two popular chromatography techniques have gained increasing attention owing to the increasing requirements of efficiency and sensitivity. In this review, we have discussed and summarized the recent advances of the online coupling of sample preparation with ultra high performance liquid chromatography and supercritical fluid chromatography techniques. The main sample preparation techniques that have been coupled with ultra high performance liquid chromatography online are solid-phase extraction and in-tube solid-phase microextraction, while solid-phase extraction and supercritical fluid extraction are the main techniques that have been coupled with supercritical fluid chromatography online. Especially, the strategies for online coupling of sample preparation with chromatography techniques were summarized. Typical applications and growing trends of the online coupling techniques were also discussed in detail. With the increasing demands of improving the efficiency, throughput, and analytical capability toward complex samples of the analysis methods, online coupling of sample preparation with chromatography techniques will acquire further development.

Enantioseparation and dissipation monitoring of oxathiapiprolin in grape using supercritical fluid chromatography tandem mass spectrometry

“…Compared with UHPLC, SFC has many advantages such as short analysis time, high resolution, as well as the low organic solvent consumption due to it combined the gas and liquid phases superior properties [19]. An environmental‐friendly mobile phase─carbon dioxide (CO 2 ) fluid own the nontoxic, nonreactive, low viscosity, and highly diffuse substance advantages, over the other widely used organic solvents, which greatly improved the separation efficiency and shortened the analysis time [20, 21]. MS is widely used in pesticides detection due to its high specificity and sensitivity.…”

Detection of Aflatoxins in Different Matrices and Food-Chain Positions

“…TurboFlow TM technology is an automatic online sample preparation method for mass spectrometric analysis of complex matrices (Liang and Zhou, 2019). TurboFlow TM technology combines the principles of diffusion, turbulence and chemistry in order to remove coextracted compounds from the matrix and capture the analyte rapidly and efficiently from the complex samples.…”

Supercritical fluid extraction–supercritical fluid chromatography of saliva: Single‐quadrupole mass spectrometry monitoring of caffeine for gastric emptying studies†

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