Recent advances of Pluronic-based copolymers functionalization in biomedical applications

Freitas, Camila Fabiano de; Santos, Jailson de Araújo; Pellosi, Diogo Silva; Caetano, Wilker; Batistela, Vagner Roberto; Muniz, Edvani C.

doi:10.1016/j.bioadv.2023.213484

Cited by 7 publications

(2 citation statements)

References 170 publications

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“…In addition, incorporation of Pluronics ® into the membrane can lead to changes in microviscosity. [34][35][36] Attempts to evaluate, fabricate, and improve DDS through experimentation are becoming more successful but still have fundamental and practical limitations. It can be difficult to resolve structural details, and methodically altering the properties of star polymers can be time-consuming and costly (e. g., composition, size, and surface charge).…”

Section: Introductionmentioning

confidence: 99%

“…Pluronics® is able to mitigate the effects of multiple drug response (MDR) by inhibiting drug efflux proteins, multiple resistance proteins and breast cancer resistant proteins. In addition, incorporation of Pluronics ® into the membrane can lead to changes in microviscosity [34–36] . Attempts to evaluate, fabricate, and improve DDS through experimentation are becoming more successful but still have fundamental and practical limitations.…”

Section: Introductionmentioning

confidence: 99%

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A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Udin,

Maarof,

Rahman

2023

ChemistrySelect

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Polymeric micelles (PM) are amphiphilic block copolymers that can form nanoscopic core/shell structures, making them highly effective for drug delivery systems (DDS). Multi‐armed starshaped poly(ethylene glycol) (PEG) polymers, a promising type of PM, provide a regulated release of drugs and can be integrated with numerous endpoints to create multifunctional drug delivery systems capable of transporting a large number of drugs. Star‐PEG polymers can also be cross‐linked to create three dimensional hydrogels with variable functionalities and sizes, increasing blood flow and reducing unanticipated drug release. In this review, we present state‐of‐the‐art computational tools for analyzing drug pharmacokinetic profiles and identifying molecular interactions critical for successful drug encapsulation in star‐PEG PM. By taking into account the features described, academic and industrial researchers can identify novel interrelationships in PM and maximize their capabilities as DDSs for systemic administration, ultimately enhancing the medicinal qualities of drug delivery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Udin,

Maarof,

Rahman

2023

ChemistrySelect

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Analysis of Macromolecular Systems as Enabler for Energy and Life Science Applications

Anufriev,

Debbeler,

Traeger

et al. 2024

Macro Chemistry & Physics

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Ideas concerning the conceptual existence of macromolecular and colloidal systems found their inception at the beginning of the last century. The experimental technology developed to discover and characterize those systems can be associated with seminal pioneers laying the foundations for microscopic, hydrodynamic, and light scattering approaches. In this perspective, we focus our attention on the origins of the discovery and characterization of macromolecular and colloidal systems with selected examples from the beginnings to the present. This perspective attempts to directly interconnect the design of new macromolecular as well as colloidal systems and the simultaneous development of using advanced characterization techniques for design verification. While not claiming a complete coverage of the entire field of modern polymer science, our selected examples concern the field of life science and the recently and rapidly developing area of energy materials.

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Application of thermo-responsive polymers as smart biomaterials in wound dressing

Rad,

Esmaeili,

Jahromi

2024

Polym. Bull.

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Recent advances of Pluronic-based copolymers functionalization in biomedical applications

Cited by 7 publications

References 170 publications

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Analysis of Macromolecular Systems as Enabler for Energy and Life Science Applications

Application of thermo-responsive polymers as smart biomaterials in wound dressing

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