Recent Advances of Salivary Gland Biopsy in Sjögren's Syndrome

Liao, Rui; Yang, Haitao; Li, Heng; Liu, Lixiong; Kai, Li; Li, Jingjing; Liang, Jianchao; Hong, Xiaoping; Chen, Yulan; Liu, Dong-Zhou

doi:10.3389/fmed.2021.792593

Cited by 23 publications

(10 citation statements)

References 105 publications

(156 reference statements)

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“…1 E). Together these results are consisted with studies showing that lymphocytic infiltration is a main trait on the progression of the pathogenesis of Sjӧgren’s syndrome, and its largely comprised by an increase of B cells, that in turns promotes inflammation [ [23] , [24] , [25] ].…”

Section: Resultssupporting

confidence: 60%

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Nascimento Da Conceicao,

Sun,

Chai

et al. 2023

Journal of Translational Autoimmunity

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Section: Resultssupporting

confidence: 60%

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Nascimento Da Conceicao,

Sun,

Chai

et al. 2023

Journal of Translational Autoimmunity

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“… A minor salivary gland biopsy is insensitive at the onset of the disease. Although it is generally a well-tolerated procedure, the risk of hemorrhage, infection, paresthesia, and mucocele formation is still present [ 91 ]. …”

Section: Current Diagnostic Challenges Encountered By Cliniciansmentioning

confidence: 99%

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

Kulbay

Tănăsescu

et al. 2023

IJMS

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Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren’s syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.

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“…In addition, structures similar to the GCs of lymphoid tissue, eGCs, are formed in the salivary glands and autoantibodies are produced in these lymphoid structures ( Figure 1 C). Following reductions in acinar cells and ductal cells, the space is often replaced by fibrous and adipose tissues [ 20 , 21 , 22 ]. When striated ductal cells are lost, terminal excretory ducts with a larger diameter will become dominant in the histology of inflamed salivary glands.…”

Section: Changes In the Salivary Gland Histology In Ssmentioning

confidence: 99%

Outline of Salivary Gland Pathogenesis of Sjögren’s Syndrome and Current Therapeutic Approaches

Yura

Hamada

2023

IJMS

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Sjögren’s syndrome (SS) is an autoimmune disease characterized by the involvement of exocrine glands such as the salivary and lacrimal glands. The minor salivary glands, from which tissue samples may be obtained, are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses of SS. In the onset of SS, autoantigens derived from the salivary glands are recognized by antigen-presenting dendritic cells, leading to the activation of T and B cells, cytokine production, autoantibody production by plasma cells, the formation of ectopic germinal centers, and the destruction of salivary gland epithelial cells. A recent therapeutic approach with immune checkpoint inhibitors for malignant tumors enhances the anti-tumor activity of cytotoxic effector T cells, but also induces SS-like autoimmune disease as an adverse event. In the treatment of xerostomia, muscarinic agonists and salivary gland duct cleansing procedure, as well as sialendoscopy, are expected to ameliorate symptoms. Clinical trials on biological therapy to attenuate the hyperresponsiveness of B cells in SS patients with systemic organ involvement have progressed. The efficacy of treatment with mesenchymal stem cells and chimeric antigen receptor T cells for SS has also been investigated. In this review, we will provide an overview of the pathogenesis of salivary gland lesions and recent trends in therapeutic approaches for SS.

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Recent Advances of Salivary Gland Biopsy in Sjögren's Syndrome

Cited by 23 publications

References 105 publications

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

Outline of Salivary Gland Pathogenesis of Sjögren’s Syndrome and Current Therapeutic Approaches

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