Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis

Zhi, Wenbing; Liu, Yang; Wang, Xiumei; Zhang, Hong

doi:10.1016/j.jep.2022.115749

Cited by 28 publications

(15 citation statements)

References 263 publications

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“…The natural compounds derived from botanical drugs containing quercetin, resveratrol, and other botanical drugs have the characteristics of multi-target, multi-pathway collaboration, by which they perform antiatherosclerotic effects through lipid-lowering, anti-inflammatory, slowing down the cell senescence, and autophagy-promoting mechanisms (Zhi et al, 2023). The mTOR signaling pathway plays an important role in the formation and development of AS.…”

Section: Discussionmentioning

confidence: 99%

“…For centuries, botanical drugs used in Traditional Chinese Medicine (TCM) have been widely practiced for the prevention and treatment of chronic heart disease. Botanical drugs have attracted widespread attention for their wide range of sources and multi-target effects (Zhi et al, 2023). Various natural agents derived from botanical drugs have been proven to have anti-AS effects (Wang et al, 2019;Penson and Banach, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Liu

et al. 2023

Front. Pharmacol.

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Atherosclerosis (AS) is a chronic inflammatory disease that is a major cause of cardiovascular diseases (CVDs), including coronary artery disease, hypertension, myocardial infarction, and heart failure. Hence, the mechanisms of AS are still being explored. A growing compendium of evidence supports that the activity of the mechanistic/mammalian target of rapamycin (mTOR) is highly correlated with the risk of AS. The mTOR signaling pathway contributes to AS progression by regulating autophagy, cell senescence, immune response, and lipid metabolism. Various botanical drugs and their functional compounds have been found to exert anti- AS effects by modulating the activity of the mTOR signaling pathway. In this review, we summarize the pathogenesis of AS based on the mTOR signaling pathway from the aspects of immune response, autophagy, cell senescence, and lipid metabolism, and comb the recent advances in natural compounds from botanical drugs to inhibit the mTOR signaling pathway and delay AS development. This review will provide a new perspective on the mechanisms and precision treatments of AS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Liu

et al. 2023

Front. Pharmacol.

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“…The injured endothelial cells will release monocyte chemoattractant protein-1 (MCP-1), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and so on to induce monocyte and macrophages to adhere to the vessel wall (Clapp et al, 2004;Chi and Melendez, 2007). Subsequently, macrophage colony stimulating factor (M-CSF) and granulocyte macrophage colony stimulating factor (GM-CSF) stimulate mononuclear macrophages to differentiate into macrophages, which will take up ox-LDL to generate foam cells and further aggravate AS (Trus et al, 2020;Zhi et al, 2023). As an important component of vascular composition, VSMC will switch from a contractile to a synthetic phenotype after endothelial cell injury.…”

Section: Endothelial Dysfunction Contributes To the Development Of Asmentioning

confidence: 99%

“…Major N. E. Br. It is a plant secondary metabolite with antioxidant activity (Zhi et al, 2023). In the past decades, quercetin has been widely used in clinical practice for various diseases due to its superior activity, including cancer, arthritis, neurodegenerative diseases and cardiovascular diseases (Wang et al, 2022).…”

Section: Ros Promotes Ox-ldl Production and Aggravates Endothelial Dy...mentioning

confidence: 99%

Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells

Ly²,

Duan³

et al. 2023

Front. Pharmacol.

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As the common pathological basis of various cardiovascular diseases, the morbidity and mortality of atherosclerosis (AS) have increased in recent years. Unfortunately, there are still many problems in the treatment of AS, and the prevention and treatment of the disease is not ideal. Up to now, the occurrence and development of AS can roughly include endothelial cell dysfunction, vascular smooth muscle cell proliferation, inflammation, foam cell production, and neoangiogenesis. Among them, endothelial dysfunction, as an early event of AS, plays a particularly important role in promoting the development of AS. In addition, oxidative stress occurs throughout the causes of endothelial dysfunction. Some previous studies have shown that flavonoids derived from herbal medicines are typical secondary metabolites. Due to its structural presence of multiple active hydroxyl groups, it is able to exert antioxidant activity in diseases. Therefore, in this review, we will search PubMed, Web of Science, Elesvier, Wliey, Springer for relevant literature, focusing on flavonoids extracted from herbal medicines, and summarizing how they can prevent endothelial dysfunction by inhibiting oxidative stress. Meanwhile, in our study, we found that flavonoid represented by quercetin and naringenin showed superior protective effects both in vivo and in vitro, suggesting the potential of flavonoid compounds in the treatment of AS.

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“…In the research field of various diseases, TCM has an inestimable prospect. All kinds of traditional Chinese medicine not only have excellent performance in relieving symptoms but also play a huge role in curing diseases [6][7][8]. In the fight against the novel coronavirus disease 2019 (COVID- 19), traditional Chinese medicines have a remarkable effect on preventing infection and curing mild infections [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

TCM Prescription Generation via Knowledge Source Guidance Network Combined with Herbal Candidate Mechanism

Hou

Song

Zhao

et al. 2023

Computational and Mathematical Methods in Medicine

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Traditional Chinese medicine (TCM) prescriptions have made great contributions to the treatment of diseases and health preservation. To alleviate the shortage of TCM resources and improve the professionalism of automatically generated prescriptions, this paper deeply explores the connection between symptoms and herbs through deep learning technology, and realizes the automatic generation of TCM prescriptions. Particularly, this paper considers the significance of referring to similar underlying prescriptions as herbal candidates in the TCM prescribing process. Moreover, this paper incorporates the idea of referring to the potential guidance information of corresponding prescriptions when model extracts symptoms representations. To provide a reference for inexperienced young TCM doctors when they prescribe, this paper proposes a dual-branch guidance strategy combined with candidate attention model (DGSCAM) to automatically generate TCM prescriptions based on symptoms text. The format of the data used this paper is the “symptoms-prescription” data pair. The specific method is as follows. First, DGSCAM realizes the extraction of key information of prescription-guided symptoms through a dual-branch network. Then, herbal candidates in the form of prescriptions that can treat symptoms are proposed in view of the compatibility knowledge of TCM prescriptions. To our knowledge, this is the first attempt to use prescriptions as herbal candidates in the prescription generation process. We conduct extensive experiments on a mixed public and clinical dataset, achieving 37.39% precision, 25.04% recall, and 29.99% F1 score, with an average doctor score of 7.7 out of 10. The experimental results show that our proposed model is valid and can generate more specialized TCM prescriptions than the baseline models. The DGSCAM developed by us has broad application scenarios and greatly promotes the research on intelligent TCM prescribing.

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Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis

Cited by 28 publications

References 263 publications

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells

TCM Prescription Generation via Knowledge Source Guidance Network Combined with Herbal Candidate Mechanism

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