Recent advances of two-dimensional materials in smart drug delivery nano-systems

Zhang, Hua; Fan, Taojian; Chen, Wen; Li, Yingchun; Wang, Bing

doi:10.1016/j.bioactmat.2020.06.012

Cited by 144 publications

(88 citation statements)

References 203 publications

(256 reference statements)

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“…Nanomaterials offer numerous attractive physical, chemical, optical, and electronic properties, such as light, thermal-responsiveness, and pH-responsiveness, which, together with their nano dimensions and relatively good biocompatibility, make them appropriate in drug delivery systems and photothermal therapy (PTT) for cancer [ 11 , 12 , 13 ]. PTT involves strong light absorption by near-infrared (NIR) responsive nanomaterials including carbon nanomaterials, with subsequent energy dissipation as heat [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

PEGylated Nanographene Oxide in Combination with Near-Infrared Laser Irradiation as a Smart Nanocarrier in Colon Cancer Targeted Therapy

et al. 2021

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Anti-cancer therapies that integrate smart nanomaterials are the focus of cancer research in recent years. Here, we present our results with PEGylated nanographene oxide particles (nGO-PEG) and have studied their combined effect with near-infrared (NIR) irradiation on low and high invasive colorectal carcinoma cells. The aim is to develop nGO-PEG as a smart nanocarrier for colon cancer-targeted therapy. For this purpose, nGO-PEG nanoparticles’ size, zeta potential, surface morphology, dispersion stability, aggregation, and sterility were determined and compared with pristine nGO nanoparticles (NPs). Our results show that PEGylation increased the particle sizes from 256.7 nm (pristine nGO) to 324.6 nm (nGO-PEG), the zeta potential from −32.9 to −21.6 mV, and wrinkled the surface of the nanosheets. Furthermore, nGO-PEG exhibited higher absorbance in the NIR region, as compared to unmodified nGO. PEGylated nGO demonstrated enhanced stability in aqueous solution, improved dispensability in the culture medium, containing 10% fetal bovine serum (FBS) and amended biocompatibility. A strong synergic effect of nGO-PEG activated with NIR irradiation for 5 min (1.5 W/cm−2 laser) was observed on cell growth inhibition of low invasive colon cancer cells (HT29) and their wound closure ability while the effect of NIR on cellular morphology was relatively weak. Our results show that PEGylation of nGO combined with NIR irradiation holds the potential for a biocompatible smart nanocarrier in colon cancer cells with enhanced physicochemical properties and higher biological compatibility. For that reason, further optimization of the irradiation process and detailed screening of nGO-PEG in combination with NIR and chemotherapeutics on the fate of the colon cancer cells is a prerequisite for highly efficient combined nanothermal and photothermal therapy for colon cancer.

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Section: Introductionmentioning

confidence: 99%

PEGylated Nanographene Oxide in Combination with Near-Infrared Laser Irradiation as a Smart Nanocarrier in Colon Cancer Targeted Therapy

et al. 2021

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“…However, several problems have been identified in clinics: too viscous, high injection resistance, uneven thickness of the liquid cushion, and unexplained mucosal shrinkage [ 23 , 29 , 30 ]. These phenomena are resulted from the absence of cationic recombination of natural SALG and its unstable viscosity in contact with the various environments of the digestive tract [ 31 ]. It can be physically ionic crosslinked rapidly at the presence of divalent cations [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection

Fan

Huang

et al. 2021

Bioactive Materials

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Endoscopic submucosal dissection (ESD) is a common procedure to treat early and precancerous gastrointestinal lesions. Via submucosal injection, a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic incision. Saline is a most common submucosal injection liquid, but the formed liquid pad lasts only a short time, and thus repeated injections increase the potential risk of adverse events. Hydrogels with high osmotic pressure and high viscosity are used as an alternate; however, with some drawbacks such as tissue damage, excessive injection resistance, and high cost. Here, we reported a nature derived hydrogel of gelatin-oxidized alginate (G-OALG). Based on the rheological analysis and compare to commercial endoscopic mucosal resection (EMR) solution (0.25% hyaluronic acid, HA), a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability, higher viscosity and more stable structures. The G-OALG gel also showed lower propulsion resistance than 0.25% HA in the injection force assessment under standard endoscopic instruments, which eased the surgical operation. In addition, the G-OALG hydrogel showed good in vivo degradability biocompatibility. By comparing the results acquired via ESD to normal saline, the G-OALG shows great histocompatibility and excellent endoscopic injectability, and enables create a longer-lasting submucosal cushion. All the features have been confirmed in the living both pig and rat models. The G-OALG could be a promising submucosal injection agent for esophageal ESD.

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“…However, this characteristics caused BPQDs suffer from rapid renal excretion and overquick degradation in the blood circulation, which limit its biomedical applications. Therefore, smart platforms that could enhance the stability of BPQDs are highly desired [ [25] , [26] , [27] ].…”

Section: Introductionmentioning

confidence: 99%

Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

Chen

Liu

Wei

et al. 2021

Bioactive Materials

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Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs) are incorporated into cysteine-based poly-(disulfide amide) (Cys-PDSA) to form stable and biodegradable nanoagent. The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles (NPs) as a novel contrast agent for high-resolution PT-OCT bioimaging. The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo . And the obtained NPs exhibit excellent near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform, with very low chemo drug dosage and side effects. Both of the polymer and BPQD are degradable, indicating this platform is a rare PT-OCT agent that is completely biodegradable. Overall, our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy.

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Recent advances of two-dimensional materials in smart drug delivery nano-systems

Cited by 144 publications

References 203 publications

PEGylated Nanographene Oxide in Combination with Near-Infrared Laser Irradiation as a Smart Nanocarrier in Colon Cancer Targeted Therapy

PEGylated Nanographene Oxide in Combination with Near-Infrared Laser Irradiation as a Smart Nanocarrier in Colon Cancer Targeted Therapy

Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection

Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

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