Recent advances on core–shell magnetic molecularly imprinted polymers for biomacromolecules

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

“…The development of MMIPs usually includes synthesis of MNPs followed by the surface protection and functionalization of these MNPs, template attachment and decoration of pre-polymerization complex with monomers and crosslinker(s) and polymerization. Template removal is performed afterwards to achieve the empty imprinted cavities for analytical applications such as recognition and isolation [ 59 ]. In the case of DDS, the last step may not be necessary.…”

“…Later on, a magnetically assisted DDS (MADDS) was introduced by Widder and coworkers in 1978, applying inorganic magnetic material in the structure of MIPs [ 58 ]. The combination of a magnetic core covered by a thin MIP shell leads to the generation of smart hybrid structures, namely magnetic MIPs (MMIPs) that provides the possibility of high drug loading and low off-target drug release followed by remote guidance, rapid distribution and local accumulation of the obtained MMIPs by using an external magnetic field [ 59 ]. Due to the good biocompatibility and chemical, thermal and mechanical stability, high sorption capacity, high selectivity, reusability, low cost and facile preparation method of the available magnetic materials, especially magnetic NPs (MNPs), the design of MMIPs as DDSs is recently become favorable [ 60 , 61 ].…”

Sample Preparation Using Molecularly Imprinted Polymers

“…To avoid the tedious centrifugation step after each step of the dSPE procedure, magnetic MIP particles can be prepared by various polymerization methods using different types of magnetic core (particles, nanotubes, nanosheet, porous structures…) as recently reviewed for MIPs developed for various types of molecules 161 or only for biomacromolecules. 152 In the most recent works involving MIP in dSPE, different types of magnetic sorbents were dispersed in the polymerization solution such as Fe3O4 NPs, 34,98 silanized Fe3O4 NPs, 43,106,162,163 vinylized Fe3O4 NPs, 52,59 PEG-Fe3O4 NPs, 96 acrylic acid-, 105 methacrylic acid-, 164 boronic acid-, 50,112 or oleic acid-Fe3O4 NPs, 165 and chitosan-Fe3O4 NPs. 62 Microspheres of Fe3O4 NPs covered by a layer of poly(GMA), 102 microporous SiO2, 42,68,69,113,114,116,[166][167][168][169][170][171][172][173][174][175][176] or TiO2 111 were also recently reported.…”

Molecular imprinting on PtPd nanoflowers for selective recognition and determination of hydrogen peroxide and glucose

“…Molecularly imprinted polymers (MIPs) could create functional polymer materials with selective recognition properties. 17 MIPs are usually prepared by bulk polymerization, photopolymerization, surface graing polymerization and sol-gel mechanisms to generate imprinting specic cavities. 18,19 Thus, combining MIPs with nanozymes provides a new class of nanozymes with improved selectivity and activity.…”