Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

Gu, Bin; Zhang, Qichun

doi:10.1002/advs.201700609

Cited by 259 publications

(153 citation statements)

References 121 publications

(219 reference statements)

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“…[14] Therefore, they were usually employed as quenchers in nanoparticle-based detection systems. [23][24][25][26][27][28] The assays involved highly distance-dependent luminescence resonance energy transfer (LRET) between energy donor and acceptor, in which the luminescent intensity changes with the separation between the energy pair. [18][19][20] The excitation may induce background fluorescence and broad emission peaks, contributing to severe cross-talking problem.…”

mentioning

confidence: 99%

“…[18][19][20] The excitation may induce background fluorescence and broad emission peaks, contributing to severe cross-talking problem. [23][24][25][26][27][28] The assays involved highly distance-dependent luminescence resonance energy transfer (LRET) between energy donor and acceptor, in which the luminescent intensity changes with the separation between the energy pair. They not only display large anti-Stokes shift [21,22] but also pose minimal damage to the gene oligos.…”

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confidence: 99%

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Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Tsang

Wong

Tsoi

et al. 2019

Adv Healthcare Materials

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Those sensors increase the limits of detection (LOD) by using signal amplifiers but the hybridization times are usually long. [7] On the other hand, colorimetric sensor produce visible color changes upon the presence of the virus genes. The simplicity in design and readout of these sensors had attracted substantial attention. Gold nanoparticles (AuNPs) are one of the promising candidates for such detection strategy because of their high extinction coefficient and aggregation-dependent color change. [8,9] Despite the advantages, AuNPs are surface-sensitive and may induce undesired aggregations due to high ionic strength and concentration of ions, resulting in false-positive signals.Apart from those approaches, optical detection has drawn substantial attention because of their simplicity, sensitiveness, and multiplexity. [10,11] It is the fact that organic dyes are widely used in conventional qPCR assays via downconversion processes. [4,12,13] However, the dyes demonstrate undesirable emissive properties such as poor photostability, broad emission band, and small Stokes shift. [14] Therefore, they were usually employed as quenchers in nanoparticle-based detection systems. [15][16][17] High energy excited quantum dots (QDs) are another representative fluorophores in downconverting assays. [18][19][20] The excitation may induce background fluorescence and broad emission peaks, contributing to severe cross-talking problem. To address these limitations, nearinfrared (NIR) triggered upconversion luminescence (UCL) in lanthanide-doped upconversion nanoparticles (UCNPs) is very promising in biodetection. They not only display large anti-Stokes shift [21,22] but also pose minimal damage to the gene oligos. In addition, the long-lived UCL signal is easily distinguished from the short-lived background signal. As a result, UCNPs were used to detect different oligos and analytes. [23][24][25][26][27][28] The assays involved highly distance-dependent luminescence resonance energy transfer (LRET) between energy donor and acceptor, in which the luminescent intensity changes with the separation between the energy pair. [29] In this work, green emitting UCNPs and AuNPs are selected as the LRET pair owing to their well-matched emission and extinction spectrum, while AuNPs exhibit excellent extinction coefficient and photostability. The size of the nanoparticles played important roles in hybridization [30] because AuNPs demonstrate sizedependent absorption property and it can alter the stability of the hybridized DNA duplex. In addition, the size ratios of the UCNPs and AuNPs affect the formation of UCNPs-AuNPs hybrid structures. Taking advantages of 808 nm excitation of With large anti-Stokes shifts and background-free signals, upconversion luminescent (UCL) screening assays have been a promising method to reduce the transmission of influenza epidemic, which can critically alleviate the disease burden and extra annual deaths. In this work, a luminescent resonance energy transfer sandwich assay is developed, which utilizes core-shell...

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confidence: 99%

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Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Tsang

Wong

Tsoi

et al. 2019

Adv Healthcare Materials

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“…Lanthanide-doped upconversion nanoparticles (Ln 3+ -doped UCNPs) can absorb two or more low energy photons and generate a single high-energy photon through a nonlinear optical process. [59,61,62] The doped lanthanides with abundant energy levels endow Ln 3+ -doped UCNPs with many energy transfer pathways for UC emissions, including excited state absorption, energy transfer upconversion, photon avalanche, cooperative energy transfer, and energy migration-mediated upconversion. [53,59] Because a near-infrared (NIR) laser is used as the excitation source, deep tissue penetration is possible due to reduced absorption and light scattering by biological tissues.…”

Section: Lanthanide-doped Upconversion Nanoparticles For Time-resolvementioning

confidence: 99%

Recent Progress in Time‐Resolved Biosensing and Bioimaging Based on Lanthanide‐Doped Nanoparticles

Wang

et al. 2019

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Luminescent nanomaterials have attracted great attention in luminescence‐based bioanalysis due to their abundant optical and tunable surface physicochemical properties. However, luminescent nanomaterials often suffer from serious autofluorescence and light scattering interference when applied to complex biological samples. Time‐resolved luminescence methodology can efficiently eliminate autofluorescence and light scattering interference by collecting the luminescence signal of a long‐lived probe after the background signals decays completely. Lanthanides have a unique [Xe]4fN electronic configuration and ladder‐like energy states, which endow lanthanide‐doped nanoparticles with many desirable optical properties, such as long luminescence lifetimes, large Stokes/anti‐Stokes shifts, and sharp emission bands. Due to their long luminescence lifetimes, lanthanide‐doped nanoparticles are widely used for high‐sensitive biosensing and high‐contrast bioimaging via time‐resolved luminescence methodology. In this review, recent progress in the development of lanthanide‐doped nanoparticles and their application in time‐resolved biosensing and bioimaging are summarized. At the end of this review, the current challenges and perspectives of lanthanide‐doped nanoparticles for time‐resolved bioapplications are discussed.

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“…Various reports are available, on detection of Cu 2+ by exploiting the photoluminescence (PL) behaviour of several moieties such as simple organic molecules, semiconductor based quantum dots (QDs), metal organic frameworks etc. . For example, a fluorescence turn‐off detection of Cu 2+ in river water was demonstrated using blue emitting branched poly(ethylenimine) (BPEI)‐functionalized carbon quantum dots (CQDs) .…”

Section: Introductionmentioning

confidence: 99%

“…Fluorescence based sensing, on the contrary, is more popular for analytes of diverse categories such as metal ions, biologically significant molecules, and environmentally harmful compounds due to its note-worthy advantages such as easy sample preparation, high sensitivity and selectivity, low cost detection, wide dynamic linear range, etc. Various reports are available, on detection of Cu 2 + by exploiting the photoluminescence (PL) behaviour of several moieties such as simple organic molecules, semiconductor based quantum dots (QDs), metal organic frameworks etc.. [8][9][10][11][12][13][14] For example, a fluorescence turn-off detection of Cu 2 + in river water was demonstrated using blue emitting branched poly(ethylenimine) (BPEI)-functionalized carbon quantum dots (CQDs). [8] The amino groups at the surface of CQDs can bind with Cu 2 + , forming cupric amine and quench the emission of fluorophore via inner filter effect.…”

Section: Introductionmentioning

confidence: 99%

Branched Ligand Ethyl 2‐Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu²⁺ Ions Probe in Aqueous Medium

Choudhary

Nageswaran

2020

ChemistrySelect

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In the present work, we explored the possibility of using a novel stabilizing ligand namely ethyl 2‐mercaptopropionate for the synthesis of CdTe quantum dots (QDs). The QDs were synthesized and stabilized by the ligand and it was realized to be emitting at 560 nm. Extensive microscopic and photo physical characterization were carried out in order to unearth the nature of the QDs synthesized. Interestingly, it was observed that, the photoluminescence emission of as synthesized QDs were getting quenched linearly in the presence of Cu2+, which prompt us to make use of these QDs for the detection of Cu2+ ions in aqueous media. A detailed mechanism of quenching was also proposed. The linear range over which the QDs was selective to Cu2+ ions was from 0.5 nM to 129.5 nM with a detection limit (LOD) of 0.5 nM providing a pathway for the QDs based Cu2+ probe.

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Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

Cited by 259 publications

References 121 publications

Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Recent Progress in Time‐Resolved Biosensing and Bioimaging Based on Lanthanide‐Doped Nanoparticles

Branched Ligand Ethyl 2‐Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu²⁺ Ions Probe in Aqueous Medium

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Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

Cited by 259 publications

References 121 publications

Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype

Recent Progress in Time‐Resolved Biosensing and Bioimaging Based on Lanthanide‐Doped Nanoparticles

Branched Ligand Ethyl 2‐Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu2+ Ions Probe in Aqueous Medium

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Branched Ligand Ethyl 2‐Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu²⁺ Ions Probe in Aqueous Medium