Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Abstract

Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

“…This technology paved its way for the past several years towards the expansion in the potential uses of nanoparticles as cosmetic products. Liposomal technologies were utilized to adjust optical properties, in order to improve its solubility and to alter its physical properties, provided for hydrophilic vesicles with phosphatidylcholine membrane(s) [37]. Nanomaterials have been used in medicinal field for therapeutic drug delivery with the focus for treatments of various diseases/disorders.…”

Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids

“…Angiogenic activity of nanoliposomal quercetin was evaluated using a chorioallantoic membrane (CAM) angiogenesis assay, coupled with digital imaging for quantification. 30,31 Nanoliposomal quercetin (5,15,25,75,150 and 300 ppm of quercetin core content) in phosphate buffer solution (0.02 mol L −1 , pH 7.4) and non-encapsulated quercetin of the same concentrations were tested. Caffeic acid was used as anti-angiogenic reference while -carotene was used as pro-angiogenic reference.…”

“…Water‐soluble compounds are incorporated into liposomes through an aqueous core compartment while lipid‐soluble and amphiphilic compounds are entrapped in phospholipid bilayers surrounding the aqueous core . Nanoliposomes have been utilized in numerous studies in the encapsulation and delivery, not just of various types of drugs, enzymes and vitamins but also of nutraceuticals including simple phenolics, polyphenolic substances, carotenoids, essential oils, and other bioactive plant extracts, with wide range of polarities . Liposomes, bearing resemblance to biological membranes, are able to enhance the bioactivities of compounds by increasing their bioavailability through improved cellular uptake.…”

“…11,12 Nanoliposomes have been utilized in numerous studies in the encapsulation and delivery, not just of various types of drugs, enzymes and vitamins but also of nutraceuticals including simple phenolics, polyphenolic substances, carotenoids, essential oils, and other bioactive plant extracts, with wide range of polarities. [13][14][15][16] Liposomes, bearing resemblance to biological membranes, are able to enhance the bioactivities of compounds by increasing their bioavailability through improved cellular uptake. Furthermore, nanoliposomal encapsulation of a bioactive substance protects it from the surrounding environment, improving its storage life and stability.…”

Current development in novel drug delivery systems of bioactive molecule plumbagin

“…They help to improve the solubility, bioavailability, intracellular uptake of components, in vitro and in vivo stability, the pharmacokinetics and bio-distribution pattern of active moieties [25]. Biocompatibility, biodegradability, site-specificity, low toxicity and ability to entrap both hydrophobic and hydrophilic molecule are the striking features of liposomes that make them highly favoured in cosmetic and pharmaceutical industries [26]. Literature revealed that numerous liposomal products are available in market and many are in various stages of clinical trials.…”