Recent advances on nanomaterials for antibacterial treatment of oral diseases

Chen, Zetong; Chu, Zhaoyou; Jiang, Yechun; Xu, Lei; Qian, Haisheng; Wang, Yuanyin; Wang, Wanni

doi:10.1016/j.mtbio.2023.100635

Cited by 21 publications

(7 citation statements)

References 116 publications

(211 reference statements)

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“…79 In the actual intraoral environment, microbial adhesion can be influenced by saliva, the presence of other microorganisms, and the extent of biofilm formation and maturation. 80 Consequently, further in vivo studies of PMMA with NCs are necessary to demonstrate clinical feasibility.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have indicated that the effects of surface energy and hydrophobicity are not significant due to their reduction by the presence of a layer of saliva or medium on the material’s surface . In the actual intraoral environment, microbial adhesion can be influenced by saliva, the presence of other microorganisms, and the extent of biofilm formation and maturation . Consequently, further in vivo studies of PMMA with NCs are necessary to demonstrate clinical feasibility.…”

Section: Discussionmentioning

confidence: 99%

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Mechanophysical and Anti-Adhesive Properties of a Nanoclay-Containing PMMA Denture Resin

Ahn,

Kim,

Lee

et al. 2024

ACS Biomater. Sci. Eng.

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Poly(methyl methacrylate) (PMMA) is commonly used for dental dentures, but it has the drawback of promoting oral health risks due to oral bacterial adhesion. Recently, various nanoparticles have been incorporated into PMMA to tackle these issues. This study aims to investigate the mechanophysical and antimicrobial adhesive properties of a denture resin by incorporating of nanoclay into PMMA. Specimens were prepared by adding 0, 1, 2, and 4 wt % surface-modified nanoclay (Sigma) to self-polymerizing PMMA denture resin. These specimens were then evaluated using FTIR, TGA/DTG, and FE-SEM with EDS. Various mechanical and surface physical properties, including nanoindentation, were measured and compared with those of pure PMMA. Antiadhesion experiments were conducted by applying a Candida albicans (ATCC 11006) suspension to the surface of the specimens. The antiadhesion activity of C. albicans was confirmed through a yeast-wall component (mannan) and mRNA-seq analysis. The bulk mechanical properties of nanoclay-PMMA composites were decreased compared to those of pure PMMA, while the flexural strength and modulus met the ISO 20795−1 requirement. However, there were no significant differences in the nanoindentation hardness and elastic modulus. The surface energy revealed a significant decrease at 4 wt % nanoclay-PMMA. The antiadhesion effect of Candida albicans was evident along with nanoclay content in the nanocomposites and confirmed by the reduced attachment of mannan on nanoclay-PMMA composites. mRNA-seq analysis supported overall transcriptome changes in altering attachment and metabolism behaviors on the surface. The nanoclay-PMMA materials showed a lower surface energy as the content increased, leading to an antiadhesion effect against Candida albicans. These findings indicate that incorporating nanoclay into PMMA surfaces could be a valuable strategy for preventing the fungal biofilm formation of denture base materials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mechanophysical and Anti-Adhesive Properties of a Nanoclay-Containing PMMA Denture Resin

Ahn,

Kim,

Lee

et al. 2024

ACS Biomater. Sci. Eng.

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“…Infectious diseases caused by multidrug-resistant bacteria are one of the most widespread problems worldwide; they cause massive challenges in the development of effective antibiotic drugs to replace conventional antibacterial [ 1 , 2 , 3 , 4 , 5 ]. In the past decade, nanoparticles (NPs) have been investigated to improve their antibacterial activity [ 6 , 7 , 8 ]. NPs are applied in various biomedical applications, such as biosensing, bioimaging, drug delivery systems, and therapeutics (antiviral, antifungal, anticancer, and antibacterial agents) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Antibacterial Therapy of Gallic Acid-Derived Carbon-Based Nanoparticles (GACNPs): Synthesis, Characterization, and Hydrogel Formulation

Dechsri,

Suwanchawalit,

Patrojanasophon

et al. 2024

Pharmaceutics

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Carbon-based nanoparticles (CNPs) have gained recognition because of their good biocompatibility, easy preparation, and excellent phototherapy properties. In biomedicine applications, CNPs are widely applied as photodynamic agents for antibacterial purposes. Photodynamic therapy has been considered a candidate for antibacterial agents because of its noninvasiveness and minimal side effects, especially in the improvement in antibacterial activity against multidrug-resistant bacteria, compared with conventional antibiotic medicines. Here, we developed CNPs from an active polyhydroxy phenolic compound, namely, gallic acid, which has abundant hydroxyl groups that can yield photodynamic effects. Gallic acid CNPs (GACNPs) were rapidly fabricated via a microwave-assisted technique at 200 °C for 20 min. GACNPs revealed notable antibacterial properties against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The minimum inhibitory concentrations of GACNPs in S. aureus and E. coli were equal at approximately 0.29 mg/mL and considerably lower than those in gallic acid solution. Furthermore, the GACNP-loaded hydrogel patches demonstrated an attractive photodynamic effect against S. aureus, and it was superior to that of Ag hydrofiber®, a commercial material. Therefore, the photodynamic properties of GACNPs can be potentially used in the development of antibacterial hydrogels for wound healing applications.

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“…Faced with the increase in the dental caries scale [1,2], it is important to find effective solutions for curing this disease. Therefore, in recent years, an upward trend in the development of antimicrobial dental composite restorative materials (DCRMs) is observed [3][4][5][6][7][8][9][10][11][12][13][14][15]. The elementary concept of providing DCRMs with antimicrobial properties assumes physically dispersing bioactive substances (such as antibiotics, antimicrobial enzymes, chlorohexidine, triclosan, metals, metal oxides, and the nanoparticles of quaternized polyethyleneimine) in available dental materials [5][6][7][8][9][10][11][12]14].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in recent years, an upward trend in the development of antimicrobial dental composite restorative materials (DCRMs) is observed [3][4][5][6][7][8][9][10][11][12][13][14][15]. The elementary concept of providing DCRMs with antimicrobial properties assumes physically dispersing bioactive substances (such as antibiotics, antimicrobial enzymes, chlorohexidine, triclosan, metals, metal oxides, and the nanoparticles of quaternized polyethyleneimine) in available dental materials [5][6][7][8][9][10][11][12]14]. As these types of biocides can easily elute from a material, the material achieved shows only a short-term antimicrobial effect.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of Dental Dimethacrylate Copolymer with Tetramethylxylylene Diisocyanate-Based Quaternary Ammonium Urethane-Dimethacrylates—Physicochemical, Mechanical, and Antibacterial Properties

Drejka,

Chrószcz-Porębska,

Kazek-Kęsik

et al. 2024

Materials

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In this study, two novel quaternary ammonium urethane-dimethacrylates (QAUDMAs) were designed for potential use as comonomers in antibacterial dental composite restorative materials. QAUDMAs were synthesized via the reaction of 1,3-bis(1-isocyanato-1-methylethyl)benzene with 2-(methacryloyloxy)ethyl-2-decylhydroxyethylmethylammonium bromide (QA10+TMXDI) and 2-(methacryloyloxy)ethyl-2-dodecylhydroxyethylmethylammonium bromide (QA12+TMXDI). Their compositions with common dental dimethacrylates comprising QAUDMA 20 wt.%, urethane-dimethacrylate monomer (UDMA) 20 wt.%, bisphenol A glycerolate dimethacrylate (Bis-GMA) 40 wt.%, and triethylene glycol dimethacrylate (TEGDMA) 20 wt.%, were photocured. The achieved copolymers were characterized for their physicochemical and mechanical properties, including their degree of conversion (DC), glass transition temperature (Tg), polymerization shrinkage (S), water contact angle (WCA), flexural modulus (E), flexural strength (FS), hardness (HB), water sorption (WS), and water leachability (WL). The antibacterial activity of the copolymers was characterized by the minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) against Staphylococcus aureus and Escherichia coli. The achieved results were compared to the properties of a typical dental copolymer comprising UDMA 40 wt.%, Bis-GMA 40 wt.%, and TEGDMA 20 wt.%. The introduction of QAUDMAs did not deteriorate physicochemical and mechanical properties. The WS and WL increased; however, they were still satisfactory. The copolymer comprising QA10+TMXDI showed a higher antibacterial effect than that comprising QA12+TMXDI and that of the reference copolymer.

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Recent advances on nanomaterials for antibacterial treatment of oral diseases

Cited by 21 publications

References 116 publications

Mechanophysical and Anti-Adhesive Properties of a Nanoclay-Containing PMMA Denture Resin

Mechanophysical and Anti-Adhesive Properties of a Nanoclay-Containing PMMA Denture Resin

Photodynamic Antibacterial Therapy of Gallic Acid-Derived Carbon-Based Nanoparticles (GACNPs): Synthesis, Characterization, and Hydrogel Formulation

Chemical Modification of Dental Dimethacrylate Copolymer with Tetramethylxylylene Diisocyanate-Based Quaternary Ammonium Urethane-Dimethacrylates—Physicochemical, Mechanical, and Antibacterial Properties

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