Recent advances on open fluidic systems for biomedical applications: A review

Oliveira, Nuno M.; Vilabril, Sara; Oliveira, Mariana B.; Reis, Rui L.; Mano, João F.

doi:10.1016/j.msec.2018.12.040

Cited by 63 publications

(41 citation statements)

References 124 publications

(269 reference statements)

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“…In the multicell nanoencapsulation, control over the number of encapsulated cells would be preferred, as suggested before, [ 1b,7,11a ] which may benefit from recent advances in microfluidics in this direction. [ 20b,56 ] The nanoencapsulation strategy could also be expanded to a partial coating of a single cell, [ 57 ] which would contribute to the controlled construction of 3D cellular architectures. Not only providing a binding motif, the partial shell might also control the cellular fate in the cellular assembly.…”

Section: Discussionmentioning

confidence: 99%

Single‐Cell Nanoencapsulation: From Passive to Active Shells

et al. 2020

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Single‐cell nanoencapsulation is an emerging field in cell‐surface engineering, emphasizing the protection of living cells against external harmful stresses in vitro and in vivo. Inspired by the cryptobiotic state found in nature, cell‐in‐shell structures are formed, which are called artificial spores and which show suppression or retardation in cell growth and division and enhanced cell survival under harsh conditions. The property requirements of the shells suggested for realization of artificial spores, such as durability, permselectivity, degradability, and functionalizability, are demonstrated with various cytocompatible materials and processes. The first‐generation shells in single‐cell nanoencapsulation are passive in the operation mode, and do not biochemically regulate the cellular metabolism or activities. Recent advances indicate that the field has shifted further toward the formation of active shells. Such shells are intimately involved in the regulation and manipulation of biological processes. Not only endowing the cells with new properties that they do not possess in their native forms, active shells also regulate cellular metabolism and/or rewire biological pathways. Recent developments in shell formation for microbial and mammalian cells are discussed and an outlook on the field is given.

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Section: Discussionmentioning

confidence: 99%

Single‐Cell Nanoencapsulation: From Passive to Active Shells

et al. 2020

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“…Open channels in reactors can use different geometries to achieve fluid confinement, [ 9 ] which are divided into two categories: (i) physical confinement [ 10 ] and (ii) wettability contrast confinement. [ 11 ] In the first method, a rectangular or triangular (cross‐section) channel with an open on one side is used to restrict and manipulate the fluid.…”

Section: Introductionmentioning

confidence: 99%

Open Flow Reactors Prepared by Laser Sintering

Guo

Yang

et al. 2021

Adv Materials Inter

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channels have one or more sides exposed to the atmosphere, which can provide the benefits for the simplicity of manufacturing, the directness of cleaning, surface modification, and deposition of catalysts. [8] These systems can also overcome the typical problems of traditional microfluidics, such as the risk of channel clogging, bulky equipment, and flow disturbances caused by bubbles. Open channels in reactors can use different geometries to achieve fluid confinement, [9] which are divided into two categories: (i) physical confinement [10] and (ii) wettability contrast confinement. [11] In the first method, a rectangular or triangular (cross-section) channel with an open on one side is used to restrict and manipulate the fluid. A channel can be formed by two opposing vertical walls; or use the narrow sides of a solid surface. In the second case, the wettability contrast constraint means that hydrophilic and hydrophobic regions are made in a specific region. And the fluid can flow in one region restricted by the virtual channel wall composed of the opposite wettability. Hydrophilic and hydrophobic regions can be formed by surface modification or oxidation, such as plasma irradiation. [12] Since the second method for the construction of the open channels is more accessible and applicable for the surface of different materials, it attracts lots of interest among chemists these years. For the successful control of surface wettability, many physical and chemical technologies have been applied, including photolithography, [13] inkjet systems, [14] UV/ozone irradiation, [15] or plasma treatment. [12] However, there are some disadvantages to the above methods. Modification with organic molecules needs lots of solvents. Photolithography is expensive. Surface wettability caused by plasma treatment and ultraviolet irradiation quickly changes over time. Plasma treatment lacks the selectivity of regions. More important, it is difficult to deposit catalysts in the channel at the same time. Therefore, it is still a challenge to develop an efficient, low-toxicity, low-cost, and simple way to realize the region's selective wettability and chemical reactivity for the fluid channel. In this paper, an open flow reactor (OFR) with wetting contrast has been successfully manufactured by direct laser sintering. [16] Laser sintering is an emerging technology for designing patterns on the surface of various materials such as plastic, metal, glass, ceramic, and wood. It is a mask-less process and can write arbitrary geometric figures directly. The laser energy can be accurately transmitted to the required location with good spatial resolution. Only the place irradiated by the laser will change its physical form or chemical composition. Therefore, laser sintering technology has broad application prospects in the design and manufacture of microreactors. [17] The open flow reactor is a kind of reactor with at least one side open to the atmosphere. Open channels have the advantages of simple surface modification, direct cleaning, and relative...

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“…Wettability is a characteristic property of a solid surface, and plays important roles in addressing the problems related to energy [1], environment [2], resources [3] and health [4]. According to the value of the wetting contact angle ( θ ), the surface wetting behaviour can generally be divided into four different regimes, superhydrophilicity for θ < 10°, hydrophilicity for 10° ≤ θ < 90°, hydrophobicity for 90° < θ ≤ 150°, and superhydrophobicity for θ > 150° [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Research on the typical microstructures and contact angles of hydrophobic plant leaves

Liu

et al. 2020

Micro & Nano Letters

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As well known, plant leaves exhibit a striking diversity of surface structures through billions of years of evolution. However, there are many issues remain unknown in the surface wettability of plant leaves. In this work, four kinds of typical plant leaves found in Nanchang University were introduced, by means of wettability and surface micromorphology with the aid of contact angle measurement and scanning electron microscopy. The surface structural models of these leaves with respect to their surface morphologies were established in terms of bionics. Meanwhile, the apparent contact angles on given surfaces were calculated using the Cassie-Baxter model. In addition, the effects of geometrical parameters of leaf surfaces on the contact angle were investigated using the Matlab software.

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Recent advances on open fluidic systems for biomedical applications: A review

Cited by 63 publications

References 124 publications

Single‐Cell Nanoencapsulation: From Passive to Active Shells

Single‐Cell Nanoencapsulation: From Passive to Active Shells

Open Flow Reactors Prepared by Laser Sintering

Research on the typical microstructures and contact angles of hydrophobic plant leaves

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