Recent advances on sources and industrial applications of lipases

Abstract

Lipases are the industrially important biocatalysts, which are envisioned to have tremendous applications in the manufacture of a wide range of products. Their unique properties such as better stability, selectivity and substrate specificity position them as the most expansively used industrial enzymes. The research on production and applications of lipases is ever growing and there exists a need to have a latest review on the research findings of lipases. The present review aims at giving the latest and broadest overall picture of research and development on lipases by including the current studies and progressions not only in the diverse industrial application fields of lipases, but also with regard to its structure, classification and sources. Also, a special emphasis has been made on the aspects such as process optimization, modeling, and design that are very critical for further scale-up and industrial implementation. The detailed tabulations provided in each section, which are prepared by the exhaustive review of current literature covering the various aspects of lipase including its production and applications along with example case studies, will serve as the comprehensive source of current advancements in lipase research. This review will be very useful for the researchers from both industry as well as academia in promoting lipolysis as the most promising approaches to intensified, greener and sustainable processes. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:5-28, 2018.

Downregulation by organic nitrogen of AOX1 promoter used for controlled expression of foreign genes in the yeast Pichia pastoris

“…In addition, in favourable thermodynamic conditions, they are also able to catalyse reactions of synthesis such as esterification and amidation. Panoply of applications for lipase has been developed (Sarmah et al, ). The gene encoding the CalB lipase from Candida antartica was fused to αMF signal peptide from S. cerevisiae and cloned under the P AOX1 promoter.…”

Biodiesel and flavor compound production using a novel promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from the psychrophilic bacterium Halocynthiibacter arcticus

“…Lipolytic enzymes such as lipases, esterases, and phospholipases catalyze the hydrolysis and transesterification of ester-containing compounds. Although these enzymes are widely distributed across the three domains of the tree of life, microbial enzymes have been extensively exploited in the fine chemical, pharmaceutical, bioenergy, pulp and paper, and food industries [ [1][2][3], see Fig. 1].…”

Characterization and Immobilization of a Novel SGNH Family Esterase (LaSGNH1) from Lactobacillus acidophilus NCFM

“…Lipolytic enzymes such as (phospho)lipases or esterases, which are present throughout three domains of life (Eukarya, Bacteria, and Archaea), are generally involved in the hydrolysis of lipids or their derivatives [1][2][3]. They share similar structural and catalytic features, including a highly conserved catalytic triad (Ser-Asp/Glu-His), an α/β hydrolase fold, broad substrate specificity, and an absence of cofactors [4,5].…”