Recent advances on synthesis and biomaterials applications of hyperbranched polymers

Cuneo, Timothy; Gao, Haifeng

doi:10.1002/wnan.1640

Cited by 38 publications

(39 citation statements)

References 180 publications

(241 reference statements)

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“…By contrast to the multi‐step laborious synthetic procedure for dendrons or dendrimers, hyperbranched polymers with the same three‐dimensional but irregular structure, containing terminal‐, linear‐, and dendritic‐regions, could be facilely prepared through a one‐pot method (Cuneo & Gao, 2020). The randomly hyperbranched architecture endow them with a low viscosity, high water‐solubility, great thermal stability, and better chemical reactivity (Bhat, Ahmadi, & Ahmad, 2018).…”

Section: Classification and Preparation Of Dendritic Polymersmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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Section: Classification and Preparation Of Dendritic Polymersmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

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“…A wide variety of potential applications have been and being developed. [1][2][3][4][5] The application depends on detailed HB architecture and the molecular structure is determined according to the polymerization kinetics. One of the classical methods to synthesize HB polymers is the step-growth polymerization of AB 2 -type monomer.…”

Section: Introductionmentioning

confidence: 99%

“…SCVP can be achieved by a wide variety of living/pseudo‐living polymerization. [ 1–5 ]…”

Section: Introductionmentioning

confidence: 99%

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Distributions of Molecular Weights and 3D Sizes of Hyperbranched Polymers Formed in Batch Self‐Condensing Vinyl Polymerization

Tobita

2020

Macro Theory & Simulations

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It is known that the step polymerization of AB 2 -type monomer leads to form random hyperbranched architecture, irrespective of the reactivity of the second B group. On the other hand, the hyperbranched structure formed in the self-condensing vinyl polymerization of AB* monomer is now shown to be nonrandom because of the persistent history-dependent connection through the A * group. The molecular weight distribution deviates from that of the random branched polymers. On the other hand, the nonrandom effect on the 3D architecture is rather small, and the expected g-ratio of the unperturbed mean-square radius of gyration 〈s 2 〉 0 of the branched molecule to that of a linear molecule for a given number k of branch points agrees well with the Zimm-Stockmayer equation that assumes random branching of primary chains having the most probable distribution.

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“…In the last decades, the interest towards the synthesis and understanding of these materials has continuously grown, representing a challenge for innovative applications. Hyperbranched polymers constitute an appealing alternative to dendrimers, owing to their facile synthesis and high tunability 11,12 . Similarly to other branched polymers, they are characterized by high exposure of functional groups, three-dimensional globular structure, low viscosity, and good solubility 13,14 .…”

mentioning

confidence: 99%

Hyperbranched DNA clusters

et al. 2020

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Recent advances on synthesis and biomaterials applications of hyperbranched polymers

Cited by 38 publications

References 180 publications

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Distributions of Molecular Weights and 3D Sizes of Hyperbranched Polymers Formed in Batch Self‐Condensing Vinyl Polymerization

Hyperbranched DNA clusters

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