“…As one of the most important heterocycles, indole is widely present in natural products and medicines due to its remarkable biological activity, such as antibacterial (Van Order and Lindwall., 1942;Bell et al, 1994), anti-obesity (Sashidhara et al, 2012), antimicrobial (Sivaprasad et al, 2006), vaginal spermicide (Paira et al, 2009), and apoptosis in acute myelogenous leukemia (AML) (Contractor et al, 2005). The functionalization of the indole core mainly occurs at the N1, C2, and C3 positions (Bandini and Eichholzer, 2009;Joucla and Djakovitch., 2009;Bartoli et al, 2010;Dalpozzo., 2015;Sandtorv., 2015;Deka et al, 2020). Among them, the C3 position modification of indoles is mainly achieved by transition metal-catalyzed C-H bond functionalization (Phipps et al, 2008;Leitch et al, 2017;Ye et al, 2020).…”