Recent and Expected Roles of Plasma‐Polymerized Films for Biomedical Applications

Abstract

This review aims to provide a summary of some of the challenges in correlating surface science and biology, with particular emphasis on areas where plasma polymerization has and will play an important role as a method to synthesize reproducible and well-defined surfaces. Since the range of possible applications of plasma polymer films in biomaterial applications is immense, this paper will focus on processes to develop various surface morphologies and chemical structures for the immobilization of proteins and cells. Functional, plasma-polymerized films are discussed as biosensitive interfaces that may ultimately be part of a multilayer system that aims at connecting inorganic/metallic transducers with biologically reactive surfaces. These topics will be reviewed with some experimental results taken from the authors' own work. Specific aspects such as adhesion improvement and solvent effects are also discussed.

Solubility and adhesion characteristics of plasma polymerized thin films derived from Lavandula angustifolia essential oil

“…3 Such tuning can be used during deposition to induce effects, such as an optical gradient in the film. 4 Plasma polymers have been implemented in a number of applications involving electronics, 5 photonics, 6 and the biomedical 7,8 fields as protective coatings or functional thin films.…”

A Review on Security Issues in Wireless Sensor Network

“…Onto this, the Au electrodes were evaporated through a shadow mask with a separation gap of 50 µm, sealed by a thin layer of SiO x , acting as an insulating coating to reduce the influence of charge screening effect during the sensor operation in buffer media. Additionally, a protective coating was prepared by a (pulsed) plasma-polymerization step [8] in a reactor that polymerizes fluorine-rich monomers (perfluoro (1,3-dimethylcyclohexane), cf. the molecular structure given in Figure 4) to a Teflon-like polymeric barrier layer, the thickness of which could be as low as 5 nm.…”

“…the molecular structure given in Figure 4) to a Teflon-like polymeric barrier layer, the thickness of which could be as low as 5 nm. This was enough to protect the semiconducting channel material yet allowed for a capacitive coupling of any bio-affinity reaction at the surface of the device in contact with the analyte solution to the conducting channel between source and drain electrode of the transistor [8].…”

Metalized Porous Interference Lithographic Microstructures via Biofunctionalization

“…[43][44][45] Tyrosine monomer was sublimated and plasma polymerized on the microframe structure, resulting in crosslinked, pinhole-free films with preserved biofunctionality, as was demonstrated earlier on different substrates (see the Experimental section). [37] The morphology and dimensions of the original template remain unchanged during vapor-based biofunctionalization and the following nanoparticle reduction (Fig.…”