Recent applications of asymmetric organocatalytic annulation reactions in natural product synthesis

Abstract

A comprehensive and updated summary of asymmetric organocatalytic annulation reactions is presented; in particular, the applications of these annulation strategies to natural products synthesis are highlighted.

A concise review on application of squaric acid derivatives and their metal complexes in medicine

“…41 Squaramides have also found wide applications in different annulation reactions. 42 Annulation reactions represent a powerful strategy for the construction of cyclic molecular frameworks. The asymmetric organocatalytic annulation reactions were used in total synthesis of natural products.…”

Chiral proline-substituted porous organic cages in asymmetric organocatalysis

“…1 In the recent decades, asymmetric organocatalysis has attracted considerable attention because of its avoidance of expensive or toxic metals and their pollution of catalytic products. [2][3][4] Immobilization of chiral functionalities on porous materials could realize enantioselective catalysis based on chiral porous materials. [5][6][7][8] To date, many solid porous materials, including metal-organic frameworks, 9 covalent organic frameworks 10 and porous organic polymers 11 have been widely employed as versatile platforms for asymmetric organocatalysis.…”

Chiral Cyclopropenimine‐catalyzed Asymmetric Michael Addition of Bulky Glycine Imine to α,β‐Unsaturated Isoxazoles

“…The asymmetric Michael additions can be realized by various chiral metal-or organo-catalysts to provide Michael adducts in high yields and enantioselectivities. [1][2][3] With the Renaissance of organocatalysis, [4][5][6][7] many chiral organocatalysts have been discovered to inspire different activation modes in organic synthesis. Among them, chiral Brønsted acids, chiral hydrogenbonding catalysts, and chiral bifunctional amines are very attractive for their structural diversity and high efficiency in catalytic asymmetric synthesis.…”

“…The asymmetric Michael addition is regarded as a very important reaction for chiral C−C and C−X (X is heteroatom) bond formations in modern organic synthesis. The asymmetric Michael additions can be realized by various chiral metal‐ or organo‐ catalysts to provide Michael adducts in high yields and enantioselectivities [1–3] . With the Renaissance of organocatalysis, [4–7] many chiral organocatalysts have been discovered to inspire different activation modes in organic synthesis.…”