Recent Applications of Multicomponent Reactions Toward Heterocyclic Drug Discovery

A Quick Access to Structurally Diverse Triazoloquinazoline Heterocycles via the MIL-101(Cr)-Catalyzed One-Pot Multi-Component Reaction of a Series of Benzaldehydes, Dimedone, and 1H-1,2,4-Triazol-3-Amine Under Green Conditions

“…The concept of multicomponent refers to combining more than two substrates in a one-pot reaction, providing more complexity and diversity in a green way. Indeed, the significance of this subject can be highlighted by the considerable number of related articles and review articles ( Khangah et al, 2021 ; Bedard et al, 2022 ; Liu et al, 2022 ). Moreover, the construction of numerous compounds that are crucial to address the necessities of our societies must be handled with key terms such as synthetic efficiency and, more importantly, atom economy by increasing the utilization of the number of atoms in the substrates that end up in the structure of the final products ( Biesen and Müller, 2021 ).…”

Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

“…MCRs are also an integral part of green chemistry, as they generate less waste and consume less energy. 13–16 Moreover, MCRs are frequently applied in the synthesis of small and simple five- and six-membered heterocyclic systems, as well as their arene/heteroarene-fused derivatives. 17–22…”