Recent Approaches in Transdermal Drug Delivery System

Stanekzai, A; Sudhakar, CK; Zhakfar, A M; Karan, Vikrant. Singh

doi:10.5958/0974-360x.2019.00783.2

Cited by 14 publications

(9 citation statements)

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“…To achieve enhanced transdermal delivery and therapeutic efficacy, drugs should have low MW (less than 1 kDa), an affinity for lipophilic and hydrophilic phases, short half-life, and a lack of skin irritability [ 64 ]. Many factors affect drug penetration through the skin, such as species differences, skin age and site, skin temperature, state of the skin, area of application, duration of exposure, moisture content of the skin, pretreatment methods, and physical characteristics of the penetrant.…”

Section: Tdds Using Chemical Enhancers (Passive Delivery)mentioning

confidence: 99%

Recent advances in transdermal drug delivery systems: a review

et al. 2021

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Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.

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Section: Tdds Using Chemical Enhancers (Passive Delivery)mentioning

confidence: 99%

Recent advances in transdermal drug delivery systems: a review

et al. 2021

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“…Chemical alterations in membrane integrity modify stratum corneum proteins and lipids to promote penetration. (DMSO and oleic acid are an example of the same [30,31]. • Pressure Sensitive Adhesives: The transdermal pharmaceutical provider's pressure-sensitive adhesive (PSA) adheres securely to the body.…”

Section: Components Of Transdermal Drug Delivery Systemmentioning

confidence: 99%

A Simple Glance at the Transdermal Drug Delivery System

Chavan¹,

Shinkar²,

Jadhav³

et al. 2022

Pharmacophore

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The Transdermal Drug Delivery Systems (TDDS), which have evolved as elements of the creation of innovative drug administrative systems, is the most important aspect of pharmaceutical dosage. The use of Transdermal patches has a systemic influence due to the penetration of the drug through the dermis. TDDS is also necessary due to its distinctive benefits. Sustained absorption, more constant plasma concentration, less first-pass metabolism, lower adverse outcomes, quick application, and the mouldability to cease medicines easily by clipping out the skin patches are some of the potential positives of transdermal pharmaceutical delivery. This method of drug delivery has many benefits over conventional oral and intravenous techniques. Ensure the fluid is released in a controlled manner with long-term treatment using drugs. As a result, numerous chemical and physical methods for developing transdermal patches are being investigated. The therapeutic application of first-generation transdermal delivery systems has steadily increased for the administration of tiny, lipophilic, low-dose medicines. Second-generation delivery systems that include chemical enhancers, non-cavitational ultrasound, and iontophoresis regulate administration rates in real-time. Third generation TDDS enhanced permeability of drugs through stratum corneum using microneedle, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound technology. This review article explains how to make different types of transdermal patches. Multiple ways for measuring transdermal dosage and the progression of TDDS were also investigated.

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“…The following mechanism can enhance drug permeation: a) Electro-osmosis (for uncharged solutes) b) Electro-repulsion used (for similar charged Solutes) c) Electro-perturbation (both charged & non charged Solutes) (Stanekzai et al, 2019).…”

Section: Iontophoresismentioning

confidence: 99%

“…Sonophoretically enhanced transdermal drug delivery system has a wide application in gene therapy and tissue engineering (Stanekzai et al, 2019). Sonophoresis transdermal drug transport can be used in the ield of biotechnology and genetic engineering (Bhatt and Aqil, 2010).…”

Section: Sonophoresismentioning

confidence: 99%

Transdermal drug delivery an emerging approach for antipsychotics

Tekawade

Nandgude

2020

ijrps

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Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.

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Recent Approaches in Transdermal Drug Delivery System

Cited by 14 publications

References 0 publications

Recent advances in transdermal drug delivery systems: a review

Recent advances in transdermal drug delivery systems: a review

A Simple Glance at the Transdermal Drug Delivery System

Transdermal drug delivery an emerging approach for antipsychotics

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