Recent Clinical and Immunological Aspects of Penicillin Allergy (Part 1 of 2)

Structure and Reactivity of β‐Lactams

“…The reaction of amines with penicillins to give penicilloyl amides (Scheme 5.7) is of interest because the major antigenic determinant of penicillin allergy is the penicilloyl group bound by an amide linkage to e-amino groups of lysine residues in proteins [114][115][116]. The aminolysis of penicillin is an amide exchange -a normally difficult process, but one which occurs readily with b-lactams [117].…”

Aminolysis of Benzylpenicillin by Aliphatic Diamines

“…IRECT AMINOLYSIS of penicillins by t-amino D groups of lysine residues on proteins has been shown to occur (1,2) and may be involved in the in viva formation of the penicilloyl-protein conjugate which is considered to be the principal antigenic determinant in penicillin allergy(3).…”