Recent Clinical Disclosures and SMR Award. Highlights from The Society
                        for Medicines Research Symposium. London, UK - December 5, 2019

Brown, Patrick O.; Butterworth, Sonia A.; Hann, Michael M.; Jeffrey, P.; Porter, Robert; Swarbrick, Martin E.; Ward, Sidne

doi:10.1358/dof.2020.45.1.3127029

Cited by 1 publication

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“…Recent advancements in peptide solid-phase synthesis, phage display technology, computer simulation, and computation, and more and more new tumor-targeting peptide-coupled drugs have led to the creation of such as the bicyclic peptide drug BT-1718 by Bicycle Therapeutics is a new type of peptide drug with a bicyclic structure [ 184 ], which can effectively overcome the problem of fast metabolism of ordinary peptide drugs in vivo. It is anticipated that future developments will leverage these novel peptides to create more stable or multifunctional tumor-targeting drugs.…”

Section: Discussionmentioning

confidence: 99%

Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies

Wang,

Zhang,

Liu

et al. 2024

Pharmaceutics

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Effective drug delivery is essential for cancer treatment. Drug delivery systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of cancer treatment. Peptides play a significant role in various biological and physiological functions and offer high design flexibility, excellent biocompatibility, adjustable morphology, and biodegradability, making them promising candidates for drug delivery. This paper reviews peptide-mediated drug delivery systems, focusing on self-assembled peptides and peptide–drug conjugates. It discusses the mechanisms and structural control of self-assembled peptides, the varieties and roles of peptide–drug conjugates, and strategies to augment peptide stability. The review concludes by addressing challenges and future directions.

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Section: Discussionmentioning

confidence: 99%