Recent  decreasing  trends  of  exposure  to  PCDDs/PCDFs/dioxin‐like  PCBs  in  general  populations,  and  associations with  diabetes,  metabolic  syndrome,  and  gout/hyperuricemia

Arisawa, Kokichi

doi:10.2152/jmi.65.151

Cited by 14 publications

(3 citation statements)

References 47 publications

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“…Median blood dioxins and dietary dioxin intake were approximately 41% lower compared with data obtained in the period 2002-2010 [42]. These results are in agreement with the recent conclusions of a review by Arisawa [72] on the associations of blood levels of dioxins with metabolic diseases, in which it was noticed that the blood levels of dioxins were decreasing, probably due to the reduction in the dietary intake of these pollutants.…”

Section: Japansupporting

confidence: 89%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

IJERPH

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Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are environmental pollutants with great persistence, the capacity of bioaccumulation, and well known important toxic effects in humans and animals. Incinerators of hazardous, municipal and medical waste, chlorine bleaching of paper pulp, cement plants, and the traffic of motor vehicles are the most frequent emission sources of these compounds. The diet, followed at a great distance by inhalation, is generally the main way of human exposure to PCDD/Fs. Human biomonitoring is of great importance to prevent potential adverse effects derived from exposure to chemicals such as PCDD/Fs. In relation to this, blood is among the most used biological monitors. In the current review, we have summarized the recent information (2000–2009) published in the scientific literature (databases: Scopus and PubMed) on the concentrations of PCDD/Fs in blood samples of non-occupationally exposed populations, as well as in some groups of occupationally exposed individuals. We have revised a number of studies conducted in various African, American, Asian and European countries, and Australia. Unfortunately, the information is quite limited. No data are available for most countries over the world. Based on the results here reviewed, where available, the current health risks for the general populations do not seem to be of concern. Moreover, taking into account the important reductions observed in the levels of PCDD/Fs in foodstuffs, new decreases in the concentrations of PCDD/Fs in blood—and other biological tissues—are very probable in the immediate years.

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Section: Japansupporting

confidence: 89%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

IJERPH

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“…Dioxins have also been detected in human milk, ranging from 5 to 15 ng TEQ/kg lipid [ 717 , 718 , 719 ]. Levels of TCDD and DCLs in the environment, and consequently in food, have been declining since the late 1970s because of reduced industrial emissions [ 720 ].…”

Section: Epigenetic Carcinogens or Carcinogens With Uncertain Mode Of...mentioning

confidence: 99%

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Kobets

Smith

Williams

2022

Foods

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Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. Carcinogens are generally present in food at low levels, resulting in low daily intakes, although there are some exceptions. Carcinogens of the DNA-reactive type produce effects at lower dosages than epigenetic carcinogens. Several food-related DNA-reactive carcinogens, including aflatoxins, aristolochic acid, benzene, benzo[a]pyrene and ethylene oxide, are recognized by the International Agency for Research on Cancer (IARC) as causes of human cancer. Of the epigenetic type, the only carcinogen considered to be associated with increased cancer in humans, although not from low-level food exposure, is dioxin (TCDD). Thus, DNA-reactive carcinogens in food represent a much greater risk than epigenetic carcinogens.

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“…Given the fact that diabetes, obesity and the metabolic syndrome are major risk factors for severe COVID-19 infections, the role of these environmental factors is even more prominent. Of course, the risk of microbial contamination has to be balanced with the potential risk of disinfection by-products [62].…”

Section: Effect Of Environmental Pollutants On Lipid Levels and Cardimentioning

confidence: 99%

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

Bornstein

Voit-Bak²,

Schmidt³

et al. 2020

Horm Metab Res

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The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic affects people around the world. However, there have been striking differences in the number of infected individuals and deaths in different countries. Particularly, within Central Europe in countries that are similar in ethnicity, age, and medical standards and have performed similar steps of containment, such differences in mortality rates remain inexplicable. We suggest to consider and explore environmental factors to explain these intriguing variations. Countries like Northern Italy, France, Spain, and UK have suffered from 5 times more deaths from the corona virus infection than neighboring countries like Germany, Switzerland, Austria, and Denmark related to the size of their respective populations. There is a striking correlation between the level of environmental pollutants including pesticides, dioxins, and air pollution such as NO2 known to affect immune function and healthy metabolism with the rate of mortality in COVID-19 pandemic in these European countries. There is also a correlation with the use of chlorination of drinking water in these regions. In addition to the improvement of environmental protective programs, there are possibilities to lower the blood levels of these pollutants by therapeutic apheresis. Furthermore, therapeutic apheresis might be an effective method to improve metabolic inflammation, altered vascular perfusion, and neurodegeneration observed as long-term complications of COVID-19 disease.

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Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin‐like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia

Cited by 14 publications

References 47 publications

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

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