Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions

Singh, Ajeet; Kumar, Sanjay; Vinayak, Manjula

doi:10.1007/s00011-018-1156-5

Cited by 23 publications

(11 citation statements)

References 264 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 Studies have shown that the plant monomer quercetin (que) has anti-inflammatory, neuroprotective, and analgesic effects, 11 and has relatively mild adverse reactions. 12 Furthermore, quercetin's pharmacological effect is achieved by activating AMPK, 13,14 and it has a significant analgesic effect on a variety of chronic pain. [13][14][15] However, whether quercetin mediates MAPKrelated analgesia through AMPK and which MAPK signaling pathways are more closely related to these problems still need further research.…”

Section: Introductionmentioning

confidence: 99%

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Ye¹,

Lin²,

Ma³

et al. 2021

JPR

View full text Add to dashboard Cite

Context: Quercetin (que) is one abundant flavonol with a variety of biological activities. Previous studies have shown quercetin can reduce neuropathic pain in rats with chronic constriction injury (CCI). Objective: To evaluate the effects of quercetin on neuropathic pain in CCI model and explore its underlying mechanism in vivo. Materials and Methods: CCI model was established by ligating the sciatic nerve of right leg on the SD rats. They were divided into ten groups: sham group, CCI model, sham+ que, CCI+ que group (30, 60, 120 mg/kg), CCI+ AICAR, CCI+ que+ compound C, CCI+etoricoxib, and the control group. They were administered for 28 days, and were performed the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) during the experiment. At the end of the experiment, sciatic nerves and spinal cord segments of rats were collected, ELISA detected the expression of inflammatory factors, detected the microglia and astrocytes with fluorescence, and Western blot detected AMPK/MAPK pathway. Results: Que could increase the MWT of CCI rats, improve the TWL of plantar, and reduce the inflammatory cells at the ligation site of the sciatic nerve. Also, que could reduce the levels of TNF-α, IL-6, and IL-1β. Western blotting results showed that p-38 MAPK, p-ERK, and p-JNK were activated in the spinal dorsal horn of CCI model group. After treatment with que and AMPK agonists, the phosphorylation levels of related proteins were inhibited. In addition, the analgesic effect of que was abolished when the AMPK inhibitor was added. Discussion and Conclusion: Quercetin alleviated the inflammatory response of sciatic nerve and spinal dorsal horn in rats induced by CCI. Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK.

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Ye¹,

Lin²,

Ma³

et al. 2021

JPR

View full text Add to dashboard Cite

show abstract

“…A great variety of compounds are released by the injured cells, and still more are synthesized during post-injury events. Whereas some of these substances directly activate nociceptors, others such as prostaglandins sensitize them [5,6]. COX enzymes are responsible for the synthesis of prostaglandins [7].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive Interaction and Pharmacokinetics of the Combination Treatments of Methyleugenol Plus Diclofenac or Ketorolac

et al. 2020

View full text Add to dashboard Cite

Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the main types of drugs used to treat pain, they have several adverse effects, and such effects can be reduced by combining two analgesic drugs. The aim of this study was to evaluate the nociceptive activity of methyleugenol combined with either diclofenac or ketorolac, and determine certain parameters of pharmacokinetics. For the isobolographic analysis, the experimental effective dose 30 (ED30) was calculated for the drugs applied individually. With these effective doses, the peak plasma concentration (Cmax) was found and the other parameters of pharmacokinetics were established. Methyleugenol plus diclofenac and methyleugenol plus ketorolac decreased licking behavior in a dose-dependent manner in phase II, with an efficacy of 32.9 ± 9.3 and 39.8 ± 9.6%, respectively. According to the isobolographic analysis, the experimental and theoretical ED30 values were similar for methyleugenol plus diclofenac, suggesting an additive effect, but significantly different for methyleugenol plus ketorolac (3.6 ± 0.5 vs. 7.7 ± 0.6 mg/kg, respectively), indicating a probable synergistic interaction. Regarding pharmacokinetics, the only parameter showing a significant difference was Cmax for the methyleugenol plus diclofenac combination. Even with this difference, the combinations studied may be advantageous for treating inflammatory pain, especially for the combination methyleugenol plus ketorolac.

show abstract

“…and enzymes (MPO, nitric oxide synthase, etc.) are also involved in the genesis of pain, signaling to the nociceptor (Singh, Kumar, & Vinayak, 2018). Accordingly, Dqv inhibition on leukocyte infiltrate was confirmed by the inhibition of MPO activity at 0.5 (12.8 μg mg -1 tissue) and 6 hours (30 μg mg -1 tissue), by 60% and 48%, respectively ( Figure 1D).…”

Section: Resultsmentioning

confidence: 70%

Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model

Assreuy

Adjafre

Sousa

et al. 2020

Acta Sci. Biol. Sci.

View full text Add to dashboard Cite

Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ''Serra de Maranguape'' (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone, and the venom secreted by the ant glands was extracted with capillary tubes, further lyophilized and maintained at -20 ± 1ºC until use. Wounds were performed in the dorsum of Swiss mice. Animals received intravenous (i.v.) injection of DqV (50 μg -1 kg day -1 ) during 3 days for evaluation of inflammatory parameters present in the wounds: hypernociception, leukocyte infiltrate, myeloperoxidase activity, nitrite nitrate -1 content. Data was tested by two-way ANOVA and Bonferroni's post-hoc test. DqV reduced (2.7 folds) hypernociception at 48 hours, leukocyte infiltration by 65% at 6 hours and myeloperoxidase activity by 60% at 0.5 hour after wound induction. In conclusion, the venom extracted from D. quadriceps glands attenuates inflammation and hypernociception in mice cutaneous wounds.

show abstract

Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions

Cited by 23 publications

References 264 publications

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Antinociceptive Interaction and Pharmacokinetics of the Combination Treatments of Methyleugenol Plus Diclofenac or Ketorolac

Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model

Contact Info

Product

Resources

About