Recent Development in Therapeutic Cardiac Patches

Mei, Xuan; Cheng, Ke

doi:10.3389/fcvm.2020.610364

Cited by 69 publications

(54 citation statements)

References 155 publications

(137 reference statements)

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“…In current clinical treatments, the transplantation of allogeneic muscle cells is significantly limited due to rejection reactions, donor site morbidity, and insufficient donor cells [ 121 ]. In addition, the delivery and retention of cells in muscle are inefficient, hindering the sustained regeneration required for sufficient functional improvement [ 122 , 123 ]. Alternative strategies are therefore required.…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

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Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

“…Alternative strategies are therefore required. Biomaterials are powerful tools to support the cellular microenvironment as well as to provide sufficient contractile strength to match native skeletal muscle [ 8 , 123 , 124 , 125 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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“…Cell sheets face the challenge of electromechanical isolation from the native myocardium, as well as vascularization resistance when the construct contains four or more cell layers ( Zhang and Jianyi, 2015 ). Cardiac patch devices are an alternative for the treatment of cardiovascular tissues after severe injuries ( Serpooshan and Ruiz-Lozano, 2014 ; Serpooshan et al, 2014 ; Mei and Cheng, 2020 ). These engineered scaffolds can act as a depository of regenerative factors and a matrix to aid targeted therapeutic delivery and sustained release ( Tomov et al, 2019 ).…”

Section: Applications Of Atessmentioning

confidence: 99%

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Chen

Gil

Ning

et al. 2021

Front. Bioeng. Biotechnol.

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A variety of suture and bioglue techniques are conventionally used to secure engineered scaffold systems onto the target tissues. These techniques, however, confront several obstacles including secondary damages, cytotoxicity, insufficient adhesion strength, improper degradation rate, and possible allergic reactions. Adhesive tissue engineering scaffolds (ATESs) can circumvent these limitations by introducing their intrinsic tissue adhesion ability. This article highlights the significance of ATESs, reviews their key characteristics and requirements, and explores various mechanisms of action to secure the scaffold onto the tissue. We discuss the current applications of advanced ATES products in various fields of tissue engineering, together with some of the key challenges for each specific field. Strategies for qualitative and quantitative assessment of adhesive properties of scaffolds are presented. Furthermore, we highlight the future prospective in the development of advanced ATES systems for regenerative medicine therapies.

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“…Cardiac patches have been devised to ameliorate the cardiac function post-MI ( Mei and Cheng, 2020 ). A cardiac patch is typically composed of substrate and active therapeutic agents ( Yang et al, 2013 ).…”

Section: Cardiac Patch Designmentioning

confidence: 99%

“…For better targeting, scientists have used proteins, antibodies, and platelet membranes to decorate their therapeutics. For better retention and integration, cardiac patches have been designed by transfer therapeutics in vehicles made of various biomaterials ( Mei and Cheng, 2020 ). Additionally, 3D printing ( Maiullari et al, 2018 ) and 3D culture ( Jackman et al, 2018 ) technologies were utilized to create replaceable cardiac tissue ( Figure 1 and Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Bioengineering Technologies for Cardiac Regenerative Medicine

Chingale

Zhu

Cheng

2021

Front. Bioeng. Biotechnol.

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Cardiac regenerative medicine faces big challenges such as a lack of adult cardiac stem cells, low turnover of mature cardiomyocytes, and difficulty in therapeutic delivery to the injured heart. The interaction of bioengineering and cardiac regenerative medicine offers innovative solutions to this field. For example, cell reprogramming technology has been applied by both direct and indirect routes to generate patient-specific cardiomyocytes. Various viral and non-viral vectors have been utilized for gene editing to intervene gene expression patterns during the cardiac remodeling process. Cell-derived protein factors, exosomes, and miRNAs have been isolated and delivered through engineered particles to overcome many innate limitations of live cell therapy. Protein decoration, antibody modification, and platelet membranes have been used for targeting and precision medicine. Cardiac patches have been used for transferring therapeutics with better retention and integration. Other technologies such as 3D printing and 3D culture have been used to create replaceable cardiac tissue. In this review, we discuss recent advancements in bioengineering and biotechnologies for cardiac regenerative medicine.

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Recent Development in Therapeutic Cardiac Patches

Cited by 69 publications

References 155 publications

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Bioengineering Technologies for Cardiac Regenerative Medicine

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