Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Abstract

Copper, an indispensable trace element within the human body, serves as an intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme‐mimicking properties, commonly known as nanozymes, possess distinct advantages over their natural enzyme counterparts, including cost‐effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated the attention of researchers, inspiring them to devise various Cu‐based nanomaterials, such as copper oxide, Cu‐MOF, and CuS, and explore their potential in enzymatic catalysis. This comprehensive review encapsulates the most recent advancements in Cu‐based nanozymes, illuminating their applications in the realm of biochemistry. Initially, we delve into the emulation of typical enzyme types achieved by Cu‐based nanomaterials. Subsequently, we discuss the latest breakthroughs concerning Cu‐based nanozymes in biochemical sensing, bacterial inhibition, cancer therapy and neurodegenerative diseases treatment. Within this segment, we also explore the modulation of Cu‐based nanozyme activity. Lastly, we present a visionary outlook for the future development of Cu‐based nanozymes.This article is protected by copyright. All rights reserved

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“… 26 Copper nanozymes not only efficiently decompose H 2 O 2 to produce oxygen but also exhibit outstanding performance in various biomedical applications due to their unique chemical properties. 27 For instance, in the field of tumor therapy, copper nanozymes have been used to alleviate tumor hypoxia, thereby enhancing the effectiveness of PDT. 28 , 29 Additionally, the choice of copper nanozymes is also based on their excellent chemical stability and tunable biological activity.…”