Recent development of electrochemical and optical aptasensors for detection of antibiotics in food monitoring applications

Zein, Muhammad Ihda H.L.; Hardianto, Ari; Irkham, Irkham; Zakiyyah, Salma Nur; Devi, Melania Janisha; Manan, Ninie Suhana Abdul; Ibrahim, Abdullahi Umar; Hartati, Yeni Wahyuni

doi:10.1016/j.jfca.2023.105644

Cited by 11 publications

(4 citation statements)

References 132 publications

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“…Biosensors utilize the specificity of biological recognition mechanisms by employing analyte recognition compounds such as enzymes, DNA probes, antibodies, aptamers, or proteins. Bioreceptors will form specific interactions with targets on the inter-surface, causing signal changes [ 101 ]. Subsequently, transducers capture signal changes from these interactions, converting them into continuous signals directly correlating with the number of molecules reacting or binding to the sensor surface.…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus

Zuliska,

Maksum,

Einaga

et al. 2024

ADMET DMPK

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Background and purpose: The increase in diabetes cases has become a major concern in the healthcare sector, necessitating the development of efficient and minimal diagnostic methods. This study aims to provide a comprehensive examination of electrochemical biosensors for detecting diabetes mellitus biomarkers, with a special focus on the utilization of carbon-based electrodes. Review approach: A detailed analysis of electrochemical biosensors incorporating various carbon electrodes, including screen-printed carbon electrodes, glassy carbon electrodes, and carbon paste electrodes, is presented. The advantages of carbon-based electrodes in biosensor design are highlighted. The review covers the detection of several key diabetes biomarkers, such as glucose, glycated hemoglobin (HbA1c), glycated human serum albumin (GHSA), insulin, and novel biomarkers. Key results: Recent developments in electrochemical biosensor technology over the last decade are summarized, emphasizing their potential in clinical applications, particularly in point-of-care settings. The utilization of carbon-based electrodes in biosensors is shown to offer significant advantages, including enhanced sensitivity, selectivity, and cost-effectiveness. Conclusion: This review underscores the importance of carbon-based electrodes in the design of electrochemical biosensors and raises awareness for the detection of novel biomarkers for more specific and personalized diabetes mellitus cases. The advancements in this field highlight the potential of these biosensors in future clinical applications, especially in point-of-care diagnostics.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus

Zuliska,

Maksum,

Einaga

et al. 2024

ADMET DMPK

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“…Due to providing methodologies with high selectivity and robustness, several electrochemical aptasensors were developed to determine antibiotics. The voltammetric, potentiometric, conductometric, and electrochemical impedance spectroscopy (EIS) techniques can be used to detect the signal generated in the biosensor device; therefore, electrochemical aptasensors are classified depending on the technique used [35].…”

Section: Antibiotics and Electrochemical Detectionmentioning

confidence: 99%

“…Antibiotic resistance is capable of increasing the severity of diseases, contributing to inefficient treatments, long hospital stays, and increased healthcare costs. In this sense, due to the importance of detecting antibiotics, selective electroanalytical methods using aptamers have stood out as promising alternatives [35]. Ikebukuro et al report the first electrochemical detection system using aptamers.…”

Section: Introductionmentioning

confidence: 99%

Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

da Silva,

Pereira

2023

Electrochem

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Aptamers are three-dimensional structures of DNA or RNA that present high affinity and selectivity to specific targets, obtained through in vitro screening. Aptamers are used as biological recognizers in electrochemical biosensors, the so-called aptasensors, providing greater specificity in recognizing the most diverse analytes. Electrochemical aptasensors have extremely relevant characteristics, such as high sensitivity, low cost compared to other biorecognizers such as antibodies, and excellent compatibility, being considered one of the most promising alternative methods in several areas, such as biomedical diagnosis and monitoring environmental contaminants. In this sense, the present work reviews the relevant aspects of methodologies based on electrochemical aptasensors and their applications in determining antibiotics, seeking to foster innovation in electrochemical biosensors.

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“…Currently, the commonly used detection methods for antibiotics are electrochemical detection [ 8 , 9 , 10 , 11 ], microbiological detection [ 12 , 13 , 14 ], and liquid chromatography–mass spectrometry [ 15 ]. Although these detection methods are highly sensitive and rapid, they are complicated, require expensive instruments and specialized operators, and are not suitable for on-site detection.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Based Sensor for Rapid and Sensitive Detection of Ofloxacin in Meat Products

Wang,

Bao,

Liu

et al. 2024

Sensors

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Ofloxacin (OFL) is widely used in animal husbandry and aquaculture due to its low price and broad spectrum of bacterial inhibition, etc. However, it is difficult to degrade and is retained in animal-derived food products, which are hazardous to human health. In this study, a simple and efficient method was developed for the detection of OFL residues in meat products. OFL coupled with amino magnetic beads by an amination reaction was used as a stationary phase. Aptamer AWO-06, which showed high affinity and specificity for OFL, was screened using the exponential enrichment (SELEX) technique. A fluorescent biosensor was developed by using AWO-06 as a probe and graphene oxide (GO) as a quencher. The OFL detection results could be obtained within 6 min. The linear range was observed in the range of 10–300 nM of the OFL concentration, and the limit of the detection of the sensor was 0.61 nM. Furthermore, the biosensor was stored at room temperature for more than 2 months, and its performance did not change. The developed biosensor in this study is easy to operate and rapid in response, and it is suitable for on-site detection. This study provided a novel method for the detection of OFL residues in meat products.

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Recent development of electrochemical and optical aptasensors for detection of antibiotics in food monitoring applications

Cited by 11 publications

References 132 publications

Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus

Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus

Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

Aptamer-Based Sensor for Rapid and Sensitive Detection of Ofloxacin in Meat Products

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