Recent Development of MOF-Based Photothermal Agent for Tumor Ablation

Abstract

Metal-organic frameworks (MOFs) are 3D-architecture compounds of metal ions and organic molecules with sufficient and permanent porosity, showing great potential as a versatile platform to load various functional moieties to endow the hybrid materials with specific applications. Currently, a variety of photothermal nanometals have been embedded into organic ligands for integrating the unique photothermal effects with the merits of MOFs to improve their performances for cancer therapy. In this review, we have summarized a series of novel MOF-based photothermal materials for this unique therapeutic modality against tumors from three main aspects according to their chemical compositions and structures, i) metal-doped MOF, ii) organic-doped MOF, and iii) polymer-coated MOF. In addition, we have summarized the latest developments and characteristics of MOF-based photothermal agents, such as good biocompatibility, low toxicity, and responsive photothermal conversion without destroying the structure of hybrid photothermal agent. At last, we addressed the future perspectives of MOF-based photothermal agent in the field of phototherapy.

Light-induced MOF synthesis enabling composite photothermal materials

“…4a ). Encouraged by the massive applicative potential of a photo-responsive MOF 50 , 51 , we set out to characterize the photothermal abilities of the composite and test it for different applications. First, we prepared three AuBP 850 @UIO-66 samples, as described above, with varying concentrations of AuBP 850 (1, 2, and 5 OD in the initial reaction vial) (see Supplementary Movie 1 for the 5 OD synthesis).…”

Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

“…PTT, also known as photothermal ablation, is a tumor therapy that uses photothermal agents to absorb light energy and convert it into thermal energy to ablate tumor cells. 140 Compared with chemotherapy, surgery, radiotherapy and other tumor therapies, PTT is minimally invasive and highly acceptable, and the NIR laser used in PTT is considered to be highly efficient and biosafe, 141 which has made great progress in the treatment of cancer. Recent studies have found that the combination of PTT and immunotherapy could not only achieve accurate treatment of local tumors by external light, but also effectively inhibit tumor recurrence and metastasis while ablating tumor.…”

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects

“…Additionally, based on their compositions and structural characteristics, MOFs-conjugate materials as photothermal agents have been classified into three groups: i) metal-doped MOFs, ii) organic-doped MOFs, and iii) polymer-coated MOFs [ 198 ]. Metal-doped MOF …”