Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine

Gao, Liangliang; Pang, Shulin; Gao, Ying; Shi, Donglei; Guo, Yuan

doi:10.1016/j.aac.2022.08.003

Cited by 15 publications

(5 citation statements)

References 98 publications

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“…Intermediates 5a – 5q were then reacted with N -bromosuccinimide (NBS) to yield substituted intermediates 6a – 6q . Finally, the Gabriel reaction , afforded intermediates 7a – 7q , which were reacted with 85% hydrazine hydrate (N 2 H 4 ·H 2 O) to yield the substituted 3-phenylbut-3-en-2-amines 8a – 8q . The target compounds 9a – 9q were obtained by a condensation reaction of 3-hydroxy-4-methoxypicolinic acid 4 and substituted 3-phenylbut-3-en-2-amines 8a – 8q (Route C).…”

Section: Resultsmentioning

confidence: 99%

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification

Dong,

Li,

Yin

et al. 2024

J. Agric. Food Chem.

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Picolinamide fungicides, structurally related to UK-2A and antimycin-A, bind into the Qi-site in the bc 1 complex. However, the detailed binding mode of picolinamide fungicides remains unknown. In the present study, antimycin-A and UK-2A were selected to study the binding mode of picolinamide inhibitors with four protonation states in the Qi-site by integrating molecular dynamics simulation, molecular docking, and molecular mechanics Generalized Born surface area (MM/GBSA) calculations. Subsequently, a series of new picolinamide derivatives were designed and synthesized to further understand the effects of substituents on the tail phenyl ring. The computational results indicated that the substituted aromatic rings in antimycin-A and UK-2A were the pharmacophore fragments and made the primary contribution when bound to a protein. Compound 9g-hydrolysis formed H-bonds with Hie201 and Ash228 and showed an IC 50 value of 6.05 ± 0.24 μM against the porcine bc 1 complex. Compound 9c, with a simpler chemical structure, showed higher control effects than florylpicoxamid against cucumber downy mildew and expanded the fungicidal spectrum of picolinamide fungicides. The structural and mechanistic insights obtained from the present study will provide a valuable clue for the future designing of new promising Qi-site inhibitors.

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Section: Resultsmentioning

confidence: 99%

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification

Dong,

Li,

Yin

et al. 2024

J. Agric. Food Chem.

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“…For confirmation and identification reasons, GC combined with GC-MS or GC-MS/MS has recently attracted interest, demonstrating the adaptability of this technology. [26][27][28][29] PGIs can be derived to create noticeable species if they are labile, lack chromophores, and have reactive functional groups. [30] The derivatization reagent can be chosen depending on the functional groups of the analyte.…”

Section: Mass Spectroscopy (Ms)mentioning

confidence: 99%

Analytical Methods and Their Significance in Pharmaceutical Process Impurities: A Review

Kumari,

Tripathy,

Gupta

2024

Macromolecular Symposia

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Potential genotoxic substances in medicines are of rising concern to pharmaceutical and regulatory authorities at detectable levels due to their potential to induce human carcinogenesis. Molecule functional groups may contribute to the genotoxicity of small molecules by converting starting materials and synthetic intermediates into reactive components. It is challenging for the pharmaceutical research and development analytical community to identify these genotoxic chemicals at trace levels without using susceptible and selective analytical methods. The literature currently needs more experimental advice for analyzing some significant contaminants. Analytical methods play a vital role in the pharmaceutical industry for monitoring and controlling impurities in drug products. These methods provide critical information on the final product's quality, purity, and efficacy by identifying unwanted substances such as degradation products, residual solvents, and process contaminants. The significance of analytical methods in pharmaceutical process impurities includes ensuring quality control, regulatory compliance, process optimization, troubleshooting, and batch release. These methods help to ensure that the final product meets the required specifications, complies with regulatory requirements, and provides the safe and effective patient treatment. The study analyses the structural alarms of commonly encountered likely genotoxic contaminants and draught regulations of various regulatory authorities to restrict the number of impurities in medicinal substances and to identify their toxicity.

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“…Growing plant diseases caused by plant pathogens promote the development of plant disease monitoring tools. Compared to those traditional bacterial detection technologies, such as polymerase chain reaction, , enzyme-linked immunosorbent assay, , immunofluorescence, , gas chromatography–mass spectrometry, , surface plasmon resonance, and electrochemical methods, the small-molecule fluorescent probes show some advantages including low cost, easy operation, and noninvasive visualization. − Therefore, more and more small-molecule fluorescent probes for bacterial imaging have been reported . However, most of them aim at human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis, and Streptococcus pneumoniae and were applied in human cell and mouse models .…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor

Guo

Wang

et al. 2022

Anal. Chem.

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Plant diseases caused by bacteria have become one of the serious problems that threaten human food security, which led to the remarkable reduction of agricultural yields and economic loss. Nitroreductase (NTR), as an important biomarker, is highly expressed in bacteria, and the level of NTR is closely related to the progression of pathogen infection. Therefore, the design of smallmolecule fluorescent sensors targeting NTR is of great significance for the detection and diagnosis of plant pathogenic bacteria. In this study, a new fluorescent sensor targeting NTR was discovered and then successfully applied to the imaging of zebraf ish and pathogenic bacteria. Most importantly, the developed sensor achieved the real-time diagnosis of Brassica napus L. infected with bacteria, which provides a promising tool for examining the temporal and spatial infection of plant pathogens in precision agriculture.

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Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine

Cited by 15 publications

References 98 publications

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification

Analytical Methods and Their Significance in Pharmaceutical Process Impurities: A Review

Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor

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Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine

Cited by 15 publications

References 98 publications

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc1 Complex and Its Structural Modification

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc1 Complex and Its Structural Modification

Analytical Methods and Their Significance in Pharmaceutical Process Impurities: A Review

Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor

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Product

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The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification

The Interaction Mechanism of Picolinamide Fungicide Targeting on the Cytochrome bc₁ Complex and Its Structural Modification