Recent developments and clinical applications of surgical glues: An overview

Jain, Ritu; Wairkar, Sarika

doi:10.1016/j.ijbiomac.2019.06.208

Cited by 55 publications

(39 citation statements)

References 86 publications

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“…[ 3,4 ] Sutureless wound closure, which mainly utilizes bioadhesives, is able to close the wounds by bonding the tissues around the wounds and has shown superiority in producing less pain and scars, enabling quick use and facilitating easy acceptance by patients in comparison with conventional sutures and staples. [ 5–7 ] In the past few years, various bioadhesives have been developed, showing adequate ability in wound closure. These bioadhesives can be conveniently applied through injection and have sufficient adhesive strength as well as low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

144

122

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Most existing bioadhesives, even those showing superiority in wound closure effectiveness, do not assist in the post-wound closure process. A bioinspired, in situ formed, double-dynamic-bond crosslinked hydrogel bioadhesive that is capable of efficiently closing open wounds and enabling post-wound closure care is reported. Catechol-modified ε-poly-l-lysine and oxidized dextran are employed as natural polymer backbones and they are in situ crosslinked using Schiff 's base dynamic bond and catecholFe coordinate dynamic bond through a process inspired by that used to cure marine mussel glue, forming a hydrogel bioadhesive. The unique double-dynamic-bond crosslinked structure endows the bioadhesive with higher mechanical and adhesive strength while retaining quick dissociation and good self-healing capacities. Accordingly, the bioadhesive can exhibit multiple desirable functions, such as dissolution on demand, repeatable adhesiveness, adhesive and mechanical strength sufficient for wound closure, injectability, and good biocompatibility (DREAMING). After efficiently closing skin incisions, the bioadhesive can be facilely removed or repeatedly close the reopened wounds, thus enabling post-wound closure care. On the basis of favorable functions in wound closure and the ability to enable post-wound closure care, the bioadhesive demonstrates great potential in dealing with skin wounds.

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Section: Introductionmentioning

confidence: 99%

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

144

122

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Section: Tissue Adhesives For Wound Closurementioning

confidence: 99%

“…Unlike topical hemostatic agents, which are often natural polymers, tissue adhesives used for wound closure in the emergency department are primarily synthetic polymers [33]. This is largely due to their high tensile strength, flexibility, and ability to form mechanical bonds [33]. The three primary classes of tissue adhesives used for wound closure are polyurethane-based tissue adhesives, polyethylene glycol-based tissue adhesives, and cyanoacrylate synthetic glues [33].…”

Section: Tissue Adhesives For Wound Closurementioning

confidence: 99%

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Thrombostatic Agents and Tissue Adhesives in the Emergency Department: Stopping the Bleeding, Closing the Wound, and Novel Applications

Jeanmonod¹,

Rammohan²,

Jeanmonod³

2020

Biosurgicals - The Next Frontier in Operative Approaches [Working Title]

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Complaints of bleeding are frequent presentations to the emergency department, and although most bleeding can be controlled with direct pressure, increased use of antiplatelet agents and anticoagulants complicates what might be otherwise simple bleeding. Industry has met the demand for hemostatic adjuncts, and a number of products are available for the emergency physician to assist in hemostatic control and wound closure. This chapter will cover the various available technologies, covering their preferred use and discussing particular bleeding scenarios and which technology may be best for each scenario.

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“…Fibrin sealants encourage haemostasis by initiating the final stage of the anticoagulation pathway and mechanically bringing tissue surfaces together (6). The apposition of the skin flap to closes" dead space" thus preventing seroma and haematoma formation.…”

Section: Introductionmentioning

confidence: 99%

The Use of Tissue Sealant in Parotidectomy -- a Systematic Review and Meta-Analysis

Rojoa

Raheman

Wright

et al. 2020

Preprint

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Background: Drains are used post-parotidectomy to reduce seroma and haematoma formation. Tissue derived thrombin sealant can enable a drainless procedure, allowing for an earlier discharge, less discomfort and a more cost-efficient method. We aimed to assess whether tissue sealant improves wound-related outcomes in parotidectomy. Method: A systematic literature review was performed using a standardised published methodology and custom database search strategy. A fixed-effect meta-analysis of the combined complications was conducted. Results: Thirteen studies were identified relating to parotidectomies using tissue sealants. Our analysis showed a statistically significant reduction in the complication rates with tissue sealant use, including haematoma and seroma (Odds Ratio 0.59 [0.36, 0.95], 95% CI, I2 =23%, P =0.03). Conclusion: The use of drains post-parotidectomy is superseded by tissue sealant due to the shorter admission time and the lower risk of post-operative complications.

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Recent developments and clinical applications of surgical glues: An overview

Cited by 55 publications

References 86 publications

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Thrombostatic Agents and Tissue Adhesives in the Emergency Department: Stopping the Bleeding, Closing the Wound, and Novel Applications

The Use of Tissue Sealant in Parotidectomy -- a Systematic Review and Meta-Analysis

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