Recent developments in biomolecule-based nanoencapsulation systems for antimicrobial delivery and biofilm disruption

Vidallon, Mark Louis P.; Teo, Boon Mian

doi:10.1039/d0cc05880g

Cited by 14 publications

(19 citation statements)

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“…Controlled release of phenolics from such systems can result from physical entrapment in structures with different geometries (e.g., gels with differing porosity, tortuosity, coated microcapsules …), from weak interactions (hydrophobic or ionic interactions, hydrogen-bonding) between phenolics and delivery systems components or from a mixture of both phenomena. Delivery systems can also be classified according to their dimensions, ranging from molecular inclusion of phenolics in cyclodextrins ( Pinho et al, 2015 ) and the rapidly growing field of nanosystems of delivery [nanoemulsions ( Saini et al, 2019 ; McClements et al, 2021 ) and nanoparticles ( Hu et al, 2017 ; Hosseini and Jafari, 2020 ; Vidallon and Teo, 2020 ; Spizzirri et al, 2021 )] to edible coatings or food packagings incorporated with antimicrobial plant phenolics ( Mir et al, 2018 ; Zhu, 2021 ), and including microemulsions and other microencapsulation systems ( Hosseini and Jafari, 2020 ). Most of systems for controlled delivery of active molecules are issued from the important effort of research for pharmaceutical applications.…”

Section: Delivery Modes To Promote the Stability And The Antimicrobial Activity Of Plant Phenolicsmentioning

confidence: 99%

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Oulahal

Degraeve

2022

Front. Microbiol.

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In recent years, the search for natural plant-based antimicrobial compounds as alternatives to some synthetic food preservatives or biocides has been stimulated by sanitary, environmental, regulatory, and marketing concerns. In this context, besides their established antioxidant activity, the antimicrobial activity of many plant phenolics deserved increased attention. Indeed, industries processing agricultural plants generate considerable quantities of phenolic-rich products and by-products, which could be valuable natural sources of natural antimicrobial molecules. Plant extracts containing volatile (e.g., essential oils) and non-volatile antimicrobial molecules can be distinguished. Plant essential oils are outside the scope of this review. This review will thus provide an overview of current knowledge regarding the promises and the limits of phenolic-rich plant extracts for food preservation and biofilm control on food-contacting surfaces. After a presentation of the major groups of antimicrobial plant phenolics, of their antimicrobial activity spectrum, and of the diversity of their mechanisms of action, their most promising sources will be reviewed. Since antimicrobial activity reduction often observed when comparing in vitro and in situ activities of plant phenolics has often been reported as a limit for their application, the effects of the composition and the microstructure of the matrices in which unwanted microorganisms are present (e.g., food and/or microbial biofilms) on their activity will be discussed. Then, the different strategies of delivery of antimicrobial phenolics to promote their activity in such matrices, such as their encapsulation or their association with edible coatings or food packaging materials are presented. The possibilities offered by encapsulation or association with polymers of packaging materials or coatings to increase the stability and ease of use of plant phenolics before their application, as well as to get systems for their controlled release are presented and discussed. Finally, the necessity to consider phenolic-rich antimicrobial plant extracts in combination with other factors consistently with hurdle technology principles will be discussed. For instance, several authors recently suggested that natural phenolic-rich extracts could not only extend the shelf-life of foods by controlling bacterial contamination, but could also coexist with probiotic lactic acid bacteria in food systems to provide enhanced health benefits to human.

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Section: Delivery Modes To Promote the Stability And The Antimicrobial Activity Of Plant Phenolicsmentioning

confidence: 99%

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Oulahal

Degraeve

2022

Front. Microbiol.

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“…While biomacromolecules are both highly abundant and inexpensive, they can also remain highly stable under a variety of process conditions and biological conditions 48 . In contrast with many other materials that are used to fabricate drug delivery systems, these molecules are often biodegradable as well as biocompatible to reduce systemic toxicity and immunogenicity 18 . Moreover, various biomacromolecules have a series of unique properties that affect the ultimate physicochemical and functional properties of nano‐assembly systems enabling them to effectively defeat tumor resistance 49 .…”

Section: The Use Of Biomacromolecules In Nano‐assemblies To Overcome ...mentioning

confidence: 99%

“…Polysaccharides are often selected as the basic frameworks of nano‐assemblies due to their unique combination of desirable properties. First, polysaccharides usually have good water solubility, which can promote the dispersion of nano‐assemblies in vivo and facilitate the delivery and stabilization of insoluble anticancer drugs 18 . Wang et al .…”

Section: The Use Of Biomacromolecules In Nano‐assemblies To Overcome ...mentioning

confidence: 99%

“…Nano‐assemblies can be made of a variety of organic or inorganic materials, among which biomacromolecules attract increasing attention thanks to their versatility and nature biocompatibility 16 . Biomacromolecules are commonly used in the preparation of biomimetic nanomaterials for drug delivery, biological imaging and bioengineering 17–20 . Here, we summarize first the main mechanisms of nano‐assembly utilization to overcome cancer drug resistance and then discuss the progress of nano‐assemblies based on various biomacromolecules, including polysaccharides, proteins and nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

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Nano‐assemblies based on biomacromolecules to overcome cancer drug resistance

Cheng

Dou

2021

Polymer International

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Overcoming tumor resistance is one of the major challenges encountered in cancer treatment. With the rapid development of nanotechnology in recent years, nano‐assemblies have become promising candidates due to their strong potential to overcome the drug resistance of tumors. They have a high degree of adaptability, including size and composition regulation, surface versatility and the possibility of combining multiple therapeutic approaches through a single nanoparticle platform. Among multiple self‐assembled component materials, biomacromolecules have attracted ever growing attention because of their unique molecular structures, natural biocompatibility and multifunctional properties. Herein, various mechanisms of nano‐assembly utilization overcoming cancer drug resistance are first summarized, and then the roles and research progress of typical biomacromolecules (such as polysaccharides, proteins and nucleic acids) in nano‐assemblies capable of overcoming cancer drug resistance are described. Finally, the potential challenges and prospects of the clinical application of biomacromolecule‐based nano‐assemblies are analyzed and discussed. © 2021 Society of Industrial Chemistry.

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“…The carrier materials act as a physicochemical barrier against environmental conditions and improve the physicochemical and biological characteristics of the encapsulated active agents. The dimensions of encapsulated product can be at the scale of nano- and micrometers [ 7 , 8 , 9 ]. Nanoscale technology has the advantages compared to microencapsulation.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Bioactive Ingredients for Their Delivery into Fermented Milk Products: A Review

2021

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The popularity and consumption of fermented milk products are growing. On the other hand, consumers are interested in health-promoting and functional foods. Fermented milk products are an excellent matrix for the incorporation of bioactive ingredients, making them functional foods. To overcome the instability or low solubility of many bioactive ingredients under various environmental conditions, the encapsulation approach was developed. This review analyzes the fortification of three fermented milk products, i.e., yogurt, cheese, and kefir with bioactive ingredients. The encapsulation methods and techniques alongside the encapsulant materials for carotenoids, phenolic compounds, omega-3, probiotics, and other micronutrients are discussed. The effect of encapsulation on the properties of bioactive ingredients themselves and on textural and sensory properties of fermented milk products is also presented.

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Recent developments in biomolecule-based nanoencapsulation systems for antimicrobial delivery and biofilm disruption

Abstract: Extensive investigation on the applications of biomolecules have led to an expanding area of study, the development of novel carriers for the delivery of antimicrobial substances. Current data on the...

Cited by 14 publications

References 101 publications

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Nano‐assemblies based on biomacromolecules to overcome cancer drug resistance

Microencapsulation of Bioactive Ingredients for Their Delivery into Fermented Milk Products: A Review

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