Recent developments in bismuth oxyhalide-based functional nanomaterials for biomedical applications

Chen, Guo-Bo; Li, Yuhao; Miao, Yuqing; Liu, Baolin

doi:10.1039/d2bm01182d

Cited by 14 publications

(4 citation statements)

References 205 publications

(320 reference statements)

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“…17,18 In particular, transition-metal-based nanocatalytic drugs have good catalytic activity and selectivity, have significant clinical potential, and have made valuable progress in recent years. 19,20 The anoxic environment in the TME leads to the overexpression of glutathione (GSH), which dramatically reduces the efficacy of the catalyst and hinders the realization of efficient exogenous stimulative catalytic therapy. 21,22 Hence, nanocatalysts with higher selectivity and catalytic activity are required.…”

Section: Introductionmentioning

confidence: 99%

“…Exogenous stimulus catalytic therapy is a strategy that uses exogenous stimuli such as near-infrared (NIR) light, ultrasound (US), or X-ray to activate catalysts and catalytic reactions for cancer treatment by many catalytic therapies. ,, Compared with the severe adverse reactions of tumor chemotherapy, the in situ conversion of nontoxic intrinsic or delivered substances into effective tumor therapeutic products has a more attractive application prospect. − To achieve this transformation in a complex TME, the catalytic activity and selectivity of nanomaterials are critical. Some nanocatalytic drugs have been developed in the past few years to guide cancer therapy’s exogenous stimulus-activated catalytic response, such as photodynamic therapy (PDT) and sonodynamic therapy (SDT). , In particular, transition-metal-based nanocatalytic drugs have good catalytic activity and selectivity, have significant clinical potential, and have made valuable progress in recent years. , …”

Section: Introductionmentioning

confidence: 99%

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Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Du,

Ping,

Wang

et al. 2024

ACS Appl. Nano Mater.

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Exogenous stimuli-activated catalytic therapies for cancer, such as photodynamic therapy, have significant clinical potential. Despite the recent progress, the low catalytic production efficiency of reactive oxygen species (ROS) and the overexpression of glutathione (GSH) in the tumor microenvironment (TME) are major challenges for exogenous stimulative catalytic therapy. Bismuth-based heterojunction nanomaterials can generate ROS under various exogenous stimuli. Based on this, we developed an exogenously excited bismuth-based heterojunction nanocatalyst Bi-Bi 2 O 3−x S x -PEG (BOP) for the photocatalytic treatment of tumors with photothermal synergism. The high photocatalytic activity of BOP is attributed to its heterojunction structure, oxygen vacancy, and local surface plasmon resonance effect, which enable suitable band potential and rapid electron transfer. The GSH consumption characteristic of BOP in TME can also enhance oxidative stress damage, amplify the toxicity of ROS, and induce cell apoptosis. BOP's remarkable photothermal conversion ability contributes to local hyperthermia and synergistic enhancement of photodynamic efficacy. This platform provides a method for constructing an efficient photocatalyst and a strategy for synergistically enhancing photocatalytic therapy by thermal damage and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Du,

Ping,

Wang

et al. 2024

ACS Appl. Nano Mater.

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“…Protoporphyrin and titanium dioxide are two extensively used sonosensitizers [18][19][20][21]. As the research object of sonosensitizers in recent years, bismuthbased nanomaterials have a fair electron-hole separation efficiency and an inferior ROS generation capacity [22][23][24][25]. Improving or modifying their structures can enhance the sonodynamic effect.…”

Section: Introductionmentioning

confidence: 99%

Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy

Chen,

Ping,

et al. 2024

Biomed. Mater.

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Chemotherapeutic agents hold significant clinical potential in combating tumors. However, delivering these drugs to the tumor site for controlled release remains a crucial challenge. In this study, we synthesize and construct a glutathione (GSH) and acid dual-responsive bismuth-based nano-delivery platform (BOD), aiming for sonodynamic enhancement of docetaxel (DTX)-mediated tumor therapy. The bismuth nanomaterial can generate multiple reactive oxygen species under ultrasound stimulation. Furthermore, the loading of DTX to form BOD effectively reduces the toxicity of DTX in the bloodstream, ensuring its cytotoxic effect is predominantly exerted at the tumor site. DTX can be well released in high expression of GSH and acidic tumor microenvironment. Meanwhile, ultrasound can also promote the release of DTX. Results from both in vitro and in vivo experiments substantiate that the synergistic therapy involving chemotherapy and sonodynamic therapy significantly inhibits the growth and proliferation of tumor cells. This study provides a favorable paradigm for developing a synergistic tumor treatment platform for tumor microenvironment response and ultrasound-promoted drug release.

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Section: Introductionmentioning

confidence: 99%

Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

Miao

et al. 2023

Adv Healthcare Materials

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As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because of its ability to penetrate deep tissue with few side effects. As the key factor of SDT, it is meaningful to design and synthesize efficient sonosensitizers. Compared with organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, inorganic sonosensitizers with stable properties, good dispersion, and long blood circulation time, have great development potential in SDT. This review summarizes possible mechanisms of SDT (sonoexcitation and ultrasonic cavitation) in detail. Based on these mechanisms, the design and synthesis of inorganic nanosonosensitizers can be divided into three categories: traditional inorganic semiconductor sonosensitizers, enhanced inorganic semiconductor sonosensitizers, and cavitation‐enhanced sonosensitizers. Subsequently, the current efficient construction methods of sonosensitizers are summarized including accelerated semiconductor charge separation and enhanced production of reactive oxygen species through ultrasonic cavitation. Furthermore, the advantages and disadvantages of different inorganic sonosensitizers and detailed strategies are systematically discussed on how to enhance SDT. Hopefully, this review could provide new insights into the design and synthesis of efficient inorganic nano‐sonosensitizers for SDT.

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Recent developments in bismuth oxyhalide-based functional nanomaterials for biomedical applications

Abstract: Multifunctional bismuth oxyhalide (BiOX, X = F, Cl, Br, and I) nanomaterials have great potential advantages in medical diagnostic and therapeutic applications. Pure BiOX nanomaterials have some limitations such as...

Cited by 14 publications

References 205 publications

Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy

Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

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