Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review

Mahmood, Khalid; Zia, Khalid Mahmood; Zuber, Mohammad; Salman, Mahwish; Anjum, Muhammad Naveed

doi:10.1016/j.ijbiomac.2015.09.026

Cited by 228 publications

(128 citation statements)

References 207 publications

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“…[28][29][30] Previously, mPEG-PLA has been employed as nanometer material to deliver doxorubicin, 31 paclitaxel 32 and 7-ethyl-10-hydroxy camptothecin 33 for cancer therapy, leading to a considerable improvement in their anticancer effects. As an amphiphilic block copolymer composed of hydrophilic and hydrophobic segments, mPEG-PLA has a tendency to self-assemble into micelles in a specific solvent.…”

Section: Discussionmentioning

confidence: 99%

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Zhu¹,

Liu²,

Wu³

et al. 2017

IJN

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Background It has been widely reported that curcumin (CUR) exhibits anticancer activity and triggers the apoptosis of human A549 non-small-cell lung cancer (NSCLC) cells. However, its application is limited owing to its poor solubility and bioavailability. Therefore, there is an urgent need to develop a new CUR formulation with higher water solubility and better biocompatibility for clinical application in the future. Materials and methods In this study, CUR-loaded methoxy polyethylene glycol–polylactide (CUR/mPEG–PLA) polymeric micelles were prepared by a thin-film hydration method. Their characteristics and antitumor effects were evaluated subsequently. Results The average size of CUR/mPEG–PLA micelles was 34.9±2.1 nm with its polydispersity index (PDI) in the range of 0.067–0.168. The encapsulation efficiency and drug loading were 90.2%±0.78% and 9.1%±0.07%, respectively. CUR was constantly released from the CUR/mPEG–PLA micelles, and its cellular uptake in A549 cells was significantly increased. It was also found that CUR/mPEG–PLA micelles inhibited A549 cell proliferation, increased the cell cytotoxicity, induced G2/M stage arrest and promoted cell apoptosis. Moreover, the CUR/mPEG–PLA micelles suppressed the migration and invasion of A549 cells more obviously than free CUR. Additionally, CUR/mPEG–PLA micelles inhibited human umbilical vein endothelial cells migration, invasion and corresponding tube formation, implying the antiangiogenesis ability. Its enhanced antitumor mechanism may be related to the reduced expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, MMP-9 and Bcl-2 as well as the increased expression of Bax. Conclusion The mPEG–PLA copolymer micelles can serve as an efficient carrier for CUR. The CUR/mPEG–PLA micelles have promising clinical potential in treating NSCLC.

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Section: Discussionmentioning

confidence: 99%

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Zhu¹,

Liu²,

Wu³

et al. 2017

IJN

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“…longa, or turmeric or saffron, is native to Asia and India and belongs to the Zingiberaceae family, and its rhizome has been used as a seasoning and in the traditional medicine since ancient times [18,25].…”

Section: Curcuma Longamentioning

confidence: 99%

“…Another problem is the rapid metabolism of curcuminoids considering the extensive biotransformation and consequent reduction in the plasmatic levels [25,60].…”

Section: Disadvantages Of Curcuma Longamentioning

confidence: 99%

Alternative Therapeutic Approach for Cartilage Repair

Akuri¹,

Barion²,

Barbalho³

et al. 2018

Cartilage Repair and Regeneration

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The cartilage is a flexible tissue, which supports the adjacent soft tissues. The damages that cause degenerative articular diseases are marked by the increase of cytokines such as tumor necrosis factor-α (TNF-α), IL-1β, IL-6, IL-18, and IL-17, which cause intense inflammatory process and release of metalloproteinases and disintegrin enzymes that lead to cartilage degradation. The Curcuma longa possessesbioactivecompoundsdesignatedascurcuminoids that display therapeutic potential in several pathologies. Curcumin is one of these compounds that may exhibit anti-inflammatory, antioxidant, antiviral, antibacterial, and antitumor effects. It may promote decrease of IL-1β,IL-6,IL-8,TNF-α,COX-2,andreactive oxygen species. Furthermore, curcumin inhibits the activity of several kinases related to the degradation of the cartilage, including tyrosine kinase, p21-activated kinase, mitogenactivated protein kinase, protein kinase C, the activator protein 1 pathway, and NF-κB leading to the suppression of the production of metalloproteinases and inflammatory cytokines. Curcumin has also been related to the stimulation of the production of type II collagen and glycosaminoglycan by chondrocytes. Studies have shown that this compound may alleviate joint pain and crepitation, reduce the use of other drugs for pain relief, stimulate the production of type II collagen and glycosaminoglycan resulting in a protective and antiinflammatory action of cartilage and bones, and improve the quality of life of the patients.

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“…In food industry, curcumin is added as a stabilizer (in jellies) or as a natural colorant, substituting artificial colorants in cheeses, pickles, mustards, cereals, soups, ice creams and yogurts (Mangolim et al, 2014). Besides its coloring capacity, curcumin also possesses antibacterial, anti-proliferative, anti-inflammatory, antioxidant and anti-carcinogenic properties (Mahmood, Zuber, Salman, & Anjum, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)

et al. 2018

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2Curcumin (E100) is a natural colorant that, besides conferring color, has bioactivity, serving as an alternative to some artificial colorants. As a hydrophobic colorant, its modification/compatibilization with the aqueous medium is required to improve stability and enable its application in hydrophilic food matrices. Herein, different formulations of curcumin (curcumin powder: PC, water-dispersible curcumin: DC: and nanoencapsulated curcumin: NC) were evaluated as yogurt colorants. PC showed the strongest bioactivity in all assays (EC50 values: 63±2 to 7.9±0.1 µg.mL -1 ; GI50 values: 48±1 to 17±1 µg.mL -1 and MIC values: 0.0625 to 0.5 mg.mL -1 ), which might indicate that DC and NC reduce the short-term accessibility to curcumin. The tested curcumin formulations produced yogurts with different appearance, specifically associated with their color parameters, besides presenting slight changes in nutritional composition and free sugars and fatty acids profiles. The water compatible formulations (DC and NC) showed advantages over hydrophobic (PC) having a wider industrial utilization.

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Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review

Cited by 228 publications

References 207 publications

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Alternative Therapeutic Approach for Cartilage Repair

Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)

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