Recent developments in enantioselective nickel(ii)-catalyzed conjugate additions

Abstract

This review highlights the recent developments in enantioselective nickel-catalyzed conjugate additions of various nucleophiles to numerous acceptor-activated olefins published since 2016. By the very fact of the lower costs of...

Silanes as a versatile hydride source for Ni–H catalysis: a promising tool for π-hydro functionalization

“…4 Compared to other frequently used transition metals, Ni stands out for its relatively low reduction potential, atomic radius, and electronegativity. 5 Moreover, Ni displays a strong affinity toward numerous sp 2 and sp systems (Fig. 1).…”

Catalytic transformations of alkenes via nickelacycles

“…21 Nickel-catalysed reactions have grown increasingly popular and significant over the past two decades, as a variety of transformations of π-components have been developed. [22][23][24][25][26][27][28] Recent efforts have focused on developing catalytic transformations of π-components via oxidative cyclometallation, primarily with activated π-components like alkynes, norbornene, allenes, α,β-unsaturated carbonyls, and 1,3-dienes. [29][30][31][32][33][34] Notably, the catalytic transformations of simple alkenes, in conjunction with other π-components through nickelacycle intermediates, have recently garnered significant interest.…”

Asymmetric cascades of the π-allyl complex: a journey from transition-metal catalysis to metallaphotocatalysis

“…Catalytic enantioselective cascades have been one of the preferred strategies for the construction of asymmetric C-C and C-X centres. [1][2][3][4][5][6][7][8][9][10][11][12] These processes are so economical and viable that they have found abundant use among the synthetic community and have been used for the synthesis of valuable bio-active natural products, pharmacophores, and synthetically useful intermediates. In this domain, the enantioselectivity could be achieved through organocatalysis or transition-metal catalysis, where a transition metal complex is used along with a chiral ligand.…”