Recent developments in hydroxyapatite coating on magnesium alloys for clinical applications

Mahmud, Saifullah; Rahman, Mostafizur; Kamruzzaman, M.; Khatun, Hazera; Ali, Md. Osman; Haque, Md Monjurul

doi:10.1016/j.rineng.2023.101002

Cited by 20 publications

(7 citation statements)

References 118 publications

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“…The combination of these phases of ACP, OCP and some pure HA are desired for HA bone cement since these phases stimulate bone reformation in vitro [ 72 , 73 ]. New studies relating to the Mg alloy coatings for orthopaedic implants are also highlighting these ACP, OCP and HA phases as being beneficial for controlled resorption [ 74 , 75 ]. The phases, combined with the morphological structure of our HA coating, confirm that we have designed a process of making highly osteoinductive coatings.…”

Section: Resultsmentioning

confidence: 99%

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

Murphy,

Morris,

Baez

2023

Nanomaterials

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This study is the second part of a two-part study whereby supersaturated solutions of calcium and phosphate ions generate well-defined hydroxyapatite coatings for orthopaedic implants. An ‘ideal’ process solution is selected from Part 1, and the detailed characterisation of films produced from this solution is undertaken here in Part 2. Analysis is presented on the hydroxyapatite produced, in both powder form and as a film upon titanium substrates representative of orthopaedic implants. From thermal analysis data, it is shown that there is bound and interstitial water present in the hydroxyapatite. Nuclear magnetic resonance data allow for the distinction between an amorphous and a crystalline component of the material. As hydroxyapatite coatings are generated, their growth mechanism is tracked across repeated process runs. A clear understanding of the growth mechanism is achieved though crystallinity and electron imaging data. Transmission electron imaging data support the proposed crystal growth and deposition mechanism. All of the data conclude that this process has a clear propensity to grow the hydroxyapatite phase of octacalcium phosphate. The investigation of the hydroxyapatite coating and its growth mechanism establish that a stable and reproducible process window has been identified. Precise control is achieved, leading to the successful formation of the desired hydroxyapatite films.

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Section: Resultsmentioning

confidence: 99%

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

Murphy,

Morris,

Baez

2023

Nanomaterials

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“…Biodegradable metal implants are the new future array towards the field of medicine and biotechnology [1,2]. Pointing out that the goal of the first generation of biomaterials is to obtain a suitable combination of material properties to replace tissues with a general combination, and to show the least toxicity in the host [3,4].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

Biomed. Lett.

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With the accumulation of data, magnesium-based degradable metal, iron-based degradable metal and zinc-based degradable metal implantable interventional devices have entered the clinic or carried out human experimental studies, and the future prospects are promising. In this paper, the definition, biodegradability and biocompatibility criteria and their classification are reviewed, and the research status and unsolved scientific problems of magnesium-based degradable metals, iron-based degradable metals and zincbased degradable metals are introduced, and the future development opportunities and challenges of degradable metals are prospected. With a deeper understanding of scientific issues such as mechanical adaptation, degradation adaptation and tissue adaptation of degradable metal implants, more new materials, new technologies and new methods of degradable metals will be developed in the future, so as to effectively realize the precise adaptation of the two events of degradable metal material degradation and body tissue repair in time and geometric space.

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Section: Introductionmentioning

confidence: 99%

Recent progress in the application of biodegradable metal implants

2024

Biomed. Lett.

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With the accumulation of data, magnesium-based degradable metal, iron-based degradable metal and zinc-based degradable metal implantable interventional devices have entered the clinic or carried out human experimental studies, and the future prospects are promising. In this paper, the definition, biodegradability and biocompatibility criteria and their classification are reviewed, and the research status and unsolved scientific problems of magnesium-based degradable metals, iron-based degradable metals and zinc-based degradable metals are introduced, and the future development opportunities and challenges of degradable metals are prospected. With a deeper understanding of scientific issues such as mechanical adaptation, degradation adaptation and tissue adaptation of degradable metal implants, more new materials, new technologies and new methods of degradable metals will be developed in the future, so as to effectively realize the precise adaptation of the two events of degradable metal material degradation and body tissue repair in time and geometric space.

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Recent developments in hydroxyapatite coating on magnesium alloys for clinical applications

Cited by 20 publications

References 118 publications

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

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Recent progress in the application of biodegradable metal implants

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